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SMILES: CCCC(CCC)Nc1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C

InChI Key: InChIKey=CNAHKPCQESLBPR-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50152186   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50152186
PNG
(CHEMBL188609 | [3-(6-Dimethylamino-4-methyl-pyridi...)
Show SMILES CCCC(CCC)Nc1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(7.26,4.55,;6.23,3.41,;4.72,3.73,;3.7,2.56,;2.18,2.87,;1.69,4.34,;.19,4.67,;4.19,1.09,;3.16,-.05,;3.63,-1.5,;2.6,-2.67,;3.09,-4.12,;1.11,-2.35,;.62,-.9,;-.79,-.27,;-.63,1.28,;-1.79,2.28,;.87,1.61,;1.64,.25,;-2.12,-1.04,;-2.12,-2.6,;-3.45,-3.37,;-4.79,-2.6,;-4.79,-1.06,;-3.45,-.27,;-3.45,1.28,;-6.13,-3.37,;-7.47,-2.6,;-6.13,-4.92,)|
Show InChI InChI=1S/C23H34N6/c1-8-10-18(11-9-2)26-21-13-16(4)25-23-22(17(5)27-29(21)23)19-14-24-20(28(6)7)12-15(19)3/h12-14,18,26H,8-11H2,1-7H3
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Article
PubMed
 4.80n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor

J Med Chem 47: 4787-98 (2004)


Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR
More data for this
Ligand-Target Pair