BDBM50152381 4-[6-Methoxy-7-(2-morpholin-4-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (benzo[1,3]dioxol-5-ylmethyl)-amide::CHEMBL187960

SMILES: COc1cc2c(ncnc2cc1OCCN1CCOCC1)N1CCN(CC1)C(=S)NCc1ccc2OCOc2c1

InChI Key: InChIKey=GVRQTPYLKDOOIU-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50152381   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50152381 (4-[6-Methoxy-7-(2-morpholin-4-yl-ethoxy)-quinazoli...) Show SMILES COc1cc2c(ncnc2cc1OCCN1CCOCC1)N1CCN(CC1)C(=S)NCc1ccc2OCOc2c1 Show InChI InChI=1S/C28H34N6O5S/c1-35-24-15-21-22(16-26(24)37-13-10-32-8-11-36-12-9-32)30-18-31-27(21)33-4-6-34(7-5-33)28(40)29-17-20-2-3-23-25(14-20)39-19-38-23/h2-3,14-16,18H,4-13,17,19H2,1H3,(H,29,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
and In Vivo Sciences Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description In vitro inhibition of Platelet derived growth factor receptor beta autophosphorylation in MG-63 cells without plasma				Bioorg Med Chem Lett 14: 4867-72 (2004) Article DOI: 10.1016/j.bmcl.2004.07.041 BindingDB Entry DOI: 10.7270/Q2VM4BQN
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50152381 (4-[6-Methoxy-7-(2-morpholin-4-yl-ethoxy)-quinazoli...) Show SMILES COc1cc2c(ncnc2cc1OCCN1CCOCC1)N1CCN(CC1)C(=S)NCc1ccc2OCOc2c1 Show InChI InChI=1S/C28H34N6O5S/c1-35-24-15-21-22(16-26(24)37-13-10-32-8-11-36-12-9-32)30-18-31-27(21)33-4-6-34(7-5-33)28(40)29-17-20-2-3-23-25(14-20)39-19-38-23/h2-3,14-16,18H,4-13,17,19H2,1H3,(H,29,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
and In Vivo Sciences Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description In vitro inhibition of Platelet derived growth factor receptor beta autophosphorylation in MG-63 cells with 45% human plasma				Bioorg Med Chem Lett 14: 4867-72 (2004) Article DOI: 10.1016/j.bmcl.2004.07.041 BindingDB Entry DOI: 10.7270/Q2VM4BQN
					More data for this Ligand-Target Pair