BDBM50153164 CHEMBL435285::N-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-N-(5-cyano-3''-ethoxy-biphenyl-2-ylmethyl)-acetamide
SMILES: CCOc1cccc(c1)-c1cc(ccc1CN(Cc1cncn1Cc1ccc(cc1)C#N)C(C)=O)C#N
InChI Key: InChIKey=JRJRLAHKHIKIEQ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit (Mus musculus) | BDBM50153164 (CHEMBL435285 | N-[3-(4-Cyano-benzyl)-3H-imidazol-4...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 16 | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Reduced farnesylation in H-Ras NIH3T3 cells | Bioorg Med Chem Lett 14: 5057-62 (2004) Article DOI: 10.1016/j.bmcl.2004.07.083 BindingDB Entry DOI: 10.7270/Q2N0160C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human)) | BDBM50153164 (CHEMBL435285 | N-[3-(4-Cyano-benzyl)-3H-imidazol-4...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibition of [3H]-GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type I | Bioorg Med Chem Lett 14: 5057-62 (2004) Article DOI: 10.1016/j.bmcl.2004.07.083 BindingDB Entry DOI: 10.7270/Q2N0160C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human)) | BDBM50153164 (CHEMBL435285 | N-[3-(4-Cyano-benzyl)-3H-imidazol-4...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into recombinant Ras CVIM by human Farnesyltransferase | Bioorg Med Chem Lett 14: 5057-62 (2004) Article DOI: 10.1016/j.bmcl.2004.07.083 BindingDB Entry DOI: 10.7270/Q2N0160C | |||||||||||
More data for this Ligand-Target Pair |