BindingDB PrimarySearch

BDBM50153176 4''-tert-Butyl-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethoxymethyl]-biphenyl-3-carbonitrile::4'-tert-butyl-6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)methyl)biphenyl-3-carbonitrile::CHEMBL184330

SMILES: CC(C)(C)c1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N

InChI Key: InChIKey=SRVLVBDYUWMIOB-UHFFFAOYSA-N

Data: 4 IC50 1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50153176
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM50153176 (4''-tert-Butyl-6-[3-(4-cyano-benzyl)-3H-imidazol-4...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.360	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of [3H]-FPP incorporation into recombinant Ras CVIM by human Farnesyltransferase				Bioorg Med Chem Lett 14: 5057-62 (2004) Article DOI: 10.1016/j.bmcl.2004.07.083 BindingDB Entry DOI: 10.7270/Q2N0160C
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50153176 (4''-tert-Butyl-6-[3-(4-cyano-benzyl)-3H-imidazol-4...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	870	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of [3H]-GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type I				Bioorg Med Chem Lett 14: 5057-62 (2004) Article DOI: 10.1016/j.bmcl.2004.07.083 BindingDB Entry DOI: 10.7270/Q2N0160C
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM50153176 (4''-tert-Butyl-6-[3-(4-cyano-benzyl)-3H-imidazol-4...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.440	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of bovine farnesyltransferase				Bioorg Med Chem Lett 14: 5371-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl Transferase (GGTase-I) (Bos taurus (bovine))	BDBM50153176 (4''-tert-Butyl-6-[3-(4-cyano-benzyl)-3H-imidazol-4...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	870	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of bovine Geranylgeranyltransferase				Bioorg Med Chem Lett 14: 5371-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit (Mus musculus)	BDBM50153176 (4''-tert-Butyl-6-[3-(4-cyano-benzyl)-3H-imidazol-4...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>100	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Reduced farnesylation in H-Ras NIH3T3 cells				Bioorg Med Chem Lett 14: 5057-62 (2004) Article DOI: 10.1016/j.bmcl.2004.07.083 BindingDB Entry DOI: 10.7270/Q2N0160C
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair