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BDBM50153307 1-[2-Hydroxy-4-isopropyl-6-(3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-3-naphthalen-2-yl-propan-1-one::CHEMBL183790

SMILES: CC(C)c1cc(O)c(C(=O)CCc2ccc3ccccc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1

InChI Key: InChIKey=PXBOULDAVSWAMD-TWHDSSIESA-N

Data: 2 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50153307   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50153307
PNG
(1-[2-Hydroxy-4-isopropyl-6-(3,4,5-trihydroxy-6-hyd...)
Show SMILES CC(C)c1cc(O)c(C(=O)CCc2ccc3ccccc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C28H32O8/c1-15(2)19-12-21(31)24(20(30)10-8-16-7-9-17-5-3-4-6-18(17)11-16)22(13-19)35-28-27(34)26(33)25(32)23(14-29)36-28/h3-7,9,11-13,15,23,25-29,31-34H,8,10,14H2,1-2H3/t23-,25-,26+,27-,28-/m1/s1
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem
Article
PubMed
150n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 2


Bioorg Med Chem Lett 14: 5121-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.082
BindingDB Entry DOI: 10.7270/Q2VD6XX2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50153307
PNG
(1-[2-Hydroxy-4-isopropyl-6-(3,4,5-trihydroxy-6-hyd...)
Show SMILES CC(C)c1cc(O)c(C(=O)CCc2ccc3ccccc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C28H32O8/c1-15(2)19-12-21(31)24(20(30)10-8-16-7-9-17-5-3-4-6-18(17)11-16)22(13-19)35-28-27(34)26(33)25(32)23(14-29)36-28/h3-7,9,11-13,15,23,25-29,31-34H,8,10,14H2,1-2H3/t23-,25-,26+,27-,28-/m1/s1
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem
Article
PubMed
8.59E+3n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition of Na-dependent [14C]-AMG uptake in CHO-K1 cells expressing human sodium glucose co-transporter 1


Bioorg Med Chem Lett 14: 5121-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.082
BindingDB Entry DOI: 10.7270/Q2VD6XX2
More data for this
Ligand-Target Pair