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BDBM50153323 CHEMBL3775276

SMILES: OC(=O)c1ccncc1NCCc1ccccc1

InChI Key: InChIKey=RNUGCABFGYLHIN-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50153323   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM50153323
PNG
(CHEMBL3775276)
Show SMILES OC(=O)c1ccncc1NCCc1ccccc1
Show InChI InChI=1S/C14H14N2O2/c17-14(18)12-7-8-15-10-13(12)16-9-6-11-4-2-1-3-5-11/h1-5,7-8,10,16H,6,9H2,(H,17,18)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 3.16E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of full length human HALO-tagged KDM4C expressed in human U2OS cells assessed as level of H3K9Me3 demethylation incubated overnight by Hoe...


J Med Chem 59: 1357-69 (2016)


BindingDB Entry DOI: 10.7270/Q2542QFT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50153323
PNG
(CHEMBL3775276)
Show SMILES OC(=O)c1ccncc1NCCc1ccccc1
Show InChI InChI=1S/C14H14N2O2/c17-14(18)12-7-8-15-10-13(12)16-9-6-11-4-2-1-3-5-11/h1-5,7-8,10,16H,6,9H2,(H,17,18)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 2.51E+3n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of human KDM6B catalytic domain using H3(20 to 36 residues)K27Me3 peptide as substrate assessed as demethylation of substrate by Rapidfire...


J Med Chem 59: 1357-69 (2016)


BindingDB Entry DOI: 10.7270/Q2542QFT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM50153323
PNG
(CHEMBL3775276)
Show SMILES OC(=O)c1ccncc1NCCc1ccccc1
Show InChI InChI=1S/C14H14N2O2/c17-14(18)12-7-8-15-10-13(12)16-9-6-11-4-2-1-3-5-11/h1-5,7-8,10,16H,6,9H2,(H,17,18)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 3.16E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of KDM4C (unknown origin) using H3K9Me3 peptide as substrate assessed as demethylation of substrate by Rapidfire mass spectrometric analys...


J Med Chem 59: 1357-69 (2016)


BindingDB Entry DOI: 10.7270/Q2542QFT
More data for this
Ligand-Target Pair