BDBM50153506 (4-Chloro-phenyl)-[(4aR,5S)-1-(4-fluoro-phenyl)-4a-methyl-4,4a,5,6,7,8-hexahydro-1H-benzo[f]indazol-5-yl]-methanol::CHEMBL362556

SMILES: C[C@]12Cc3cnn(c3C=C1CCC[C@@H]2C(O)c1ccc(Cl)cc1)-c1ccc(F)cc1

InChI Key: InChIKey=FSHOAPBVJOOOBU-KIDMSAQOSA-N

Data: 1 IC50  3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50153506   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid (RAT)	BDBM50153506 ((4-Chloro-phenyl)-[(4aR,5S)-1-(4-fluoro-phenyl)-4a...) Show SMILES C[C@]12Cc3cnn(c3C=C1CCC[C@@H]2C(O)c1ccc(Cl)cc1)-c1ccc(F)cc1 |c:9| Show InChI InChI=1S/C25H24ClFN2O/c1-25-14-17-15-28-29(21-11-9-20(27)10-12-21)23(17)13-18(25)3-2-4-22(25)24(30)16-5-7-19(26)8-6-16/h5-13,15,22,24,30H,2-4,14H2,1H3/t22-,24?,25+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
University of California--San Francisco Curated by ChEMBL					Assay Description Repression of AP1-luciferase reporter activity in TPA-stimulated U2OS cells expressing rat glucocorticoid receptor				Bioorg Med Chem Lett 14: 5199-203 (2004) Article DOI: 10.1016/j.bmcl.2004.07.052 BindingDB Entry DOI: 10.7270/Q2G73D65
					More data for this Ligand-Target Pair
Glucocorticoid (RAT)	BDBM50153506 ((4-Chloro-phenyl)-[(4aR,5S)-1-(4-fluoro-phenyl)-4a...) Show SMILES C[C@]12Cc3cnn(c3C=C1CCC[C@@H]2C(O)c1ccc(Cl)cc1)-c1ccc(F)cc1 |c:9| Show InChI InChI=1S/C25H24ClFN2O/c1-25-14-17-15-28-29(21-11-9-20(27)10-12-21)23(17)13-18(25)3-2-4-22(25)24(30)16-5-7-19(26)8-6-16/h5-13,15,22,24,30H,2-4,14H2,1H3/t22-,24?,25+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
University of California--San Francisco Curated by ChEMBL					Assay Description Inhibition against U2OS cells expressing rat Glucocorticoid receptor				Bioorg Med Chem Lett 14: 5199-203 (2004) Article DOI: 10.1016/j.bmcl.2004.07.052 BindingDB Entry DOI: 10.7270/Q2G73D65
					More data for this Ligand-Target Pair
Glucocorticoid (RAT)	BDBM50153506 ((4-Chloro-phenyl)-[(4aR,5S)-1-(4-fluoro-phenyl)-4a...) Show SMILES C[C@]12Cc3cnn(c3C=C1CCC[C@@H]2C(O)c1ccc(Cl)cc1)-c1ccc(F)cc1 |c:9| Show InChI InChI=1S/C25H24ClFN2O/c1-25-14-17-15-28-29(21-11-9-20(27)10-12-21)23(17)13-18(25)3-2-4-22(25)24(30)16-5-7-19(26)8-6-16/h5-13,15,22,24,30H,2-4,14H2,1H3/t22-,24?,25+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
University of California--San Francisco Curated by ChEMBL					Assay Description Effective concentration against MMTV in transactivation assay in U2OS cells expressing rat GR				Bioorg Med Chem Lett 14: 5199-203 (2004) Article DOI: 10.1016/j.bmcl.2004.07.052 BindingDB Entry DOI: 10.7270/Q2G73D65
					More data for this Ligand-Target Pair
Glucocorticoid (RAT)	BDBM50153506 ((4-Chloro-phenyl)-[(4aR,5S)-1-(4-fluoro-phenyl)-4a...) Show SMILES C[C@]12Cc3cnn(c3C=C1CCC[C@@H]2C(O)c1ccc(Cl)cc1)-c1ccc(F)cc1 |c:9| Show InChI InChI=1S/C25H24ClFN2O/c1-25-14-17-15-28-29(21-11-9-20(27)10-12-21)23(17)13-18(25)3-2-4-22(25)24(30)16-5-7-19(26)8-6-16/h5-13,15,22,24,30H,2-4,14H2,1H3/t22-,24?,25+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
University of California--San Francisco Curated by ChEMBL					Assay Description Repression of NFkB-luciferase reporter activity in TPA stimulated U2OS cells expressing rat glucocorticoid receptor				Bioorg Med Chem Lett 14: 5199-203 (2004) Article DOI: 10.1016/j.bmcl.2004.07.052 BindingDB Entry DOI: 10.7270/Q2G73D65
					More data for this Ligand-Target Pair