BDBM50153776 5-((5-(((5-cyano-3'-ethoxybiphenyl-2-yl)methoxy)methyl)-1H-imidazol-1-yl)methyl)picolinonitrile::5-[5-(5-Cyano-3''-ethoxy-biphenyl-2-ylmethoxymethyl)-imidazol-1-ylmethyl]-pyridine-2-carbonitrile::CHEMBL183953
SMILES: CCOc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(nc1)C#N)C#N
InChI Key: InChIKey=KHSJUCKXCHDAKT-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Geranylgeranyl Transferase (GGTase-I) (Bos taurus (bovine)) | BDBM50153776 (5-((5-(((5-cyano-3'-ethoxybiphenyl-2-yl)methoxy)me...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibition of bovine Geranylgeranyltransferase | Bioorg Med Chem Lett 14: 5371-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit (Mus musculus) | BDBM50153776 (5-((5-(((5-cyano-3'-ethoxybiphenyl-2-yl)methoxy)me...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 17 | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibition of H-Ras transformed NIH-3T3-cell proliferation | Bioorg Med Chem Lett 14: 5371-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Farnesyltransferase (PFT) (Bos taurus (bovine)) | BDBM50153776 (5-((5-(((5-cyano-3'-ethoxybiphenyl-2-yl)methoxy)me...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.580 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibition of bovine farnesyltransferase | Bioorg Med Chem Lett 14: 5371-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8 | |||||||||||
More data for this Ligand-Target Pair |