BindingDB PrimarySearch

BDBM50153846 4-methyl-1-[3-(1,4-oxazinan-4-yl)phenylcarboxamido]-3-[4-(1,3-thiazol-4-ylmethoxy)phenylcarboxamido]benzene::CHEMBL183630

SMILES: Cc1ccc(NC(=O)c2cccc(c2)N2CCOCC2)cc1NC(=O)c1ccc(OCc2cscn2)cc1

InChI Key: InChIKey=JBPMUXHYANUBMJ-UHFFFAOYSA-N

Data: 8 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50153846
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50153846 (4-methyl-1-[3-(1,4-oxazinan-4-yl)phenylcarboxamido...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Concentration required to inhibit human mitogen activated protein kinase p38 activity				Bioorg Med Chem Lett 14: 5383-7 (2004) Article DOI: 10.1016/j.bmcl.2004.08.006 BindingDB Entry DOI: 10.7270/Q28G8K57
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair
G-protein- coupled-like receptor Smoothened (Smo) (Homo sapiens (Human))	BDBM50153846 (4-methyl-1-[3-(1,4-oxazinan-4-yl)phenylcarboxamido...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of Smo expressed in mouse NIH/3T3 cells after 20 hrs by Gli reporter gene assay				Bioorg Med Chem Lett 22: 4907-11 (2012) Article DOI: 10.1016/j.bmcl.2012.04.104 BindingDB Entry DOI: 10.7270/Q2W37XCG
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50153846 (4-methyl-1-[3-(1,4-oxazinan-4-yl)phenylcarboxamido...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of p38alpha				Bioorg Med Chem Lett 22: 4907-11 (2012) Article DOI: 10.1016/j.bmcl.2012.04.104 BindingDB Entry DOI: 10.7270/Q2W37XCG
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50153846 (4-methyl-1-[3-(1,4-oxazinan-4-yl)phenylcarboxamido...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.26E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of p38alpha-mediated TNFalpha secretion in LPS-stimulated human whole blood				Bioorg Med Chem Lett 22: 3879-83 (2012) Article DOI: 10.1016/j.bmcl.2012.04.116 BindingDB Entry DOI: 10.7270/Q2VH5PWC
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50153846 (4-methyl-1-[3-(1,4-oxazinan-4-yl)phenylcarboxamido...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25.1	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of p38alpha-mediated TNFalpha secretion in LPS-stimulated human whole blood assessed as IC50 equals to free drug concentration at human wh...				Bioorg Med Chem Lett 22: 3879-83 (2012) Article DOI: 10.1016/j.bmcl.2012.04.116 BindingDB Entry DOI: 10.7270/Q2VH5PWC
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50153846 (4-methyl-1-[3-(1,4-oxazinan-4-yl)phenylcarboxamido...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of p38alpha kinase				Bioorg Med Chem Lett 22: 3879-83 (2012) Article DOI: 10.1016/j.bmcl.2012.04.116 BindingDB Entry DOI: 10.7270/Q2VH5PWC
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50153846 (4-methyl-1-[3-(1,4-oxazinan-4-yl)phenylcarboxamido...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15.8	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of p38alpha kinase				Bioorg Med Chem Lett 22: 3879-83 (2012) Article DOI: 10.1016/j.bmcl.2012.04.116 BindingDB Entry DOI: 10.7270/Q2VH5PWC
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50153846 (4-methyl-1-[3-(1,4-oxazinan-4-yl)phenylcarboxamido...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of p38alpha-mediated TNFalpha secretion in LPS-stimulated human whole blood				Bioorg Med Chem Lett 22: 3879-83 (2012) Article DOI: 10.1016/j.bmcl.2012.04.116 BindingDB Entry DOI: 10.7270/Q2VH5PWC
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair