BDBM50153973 4-[2-(4,6-Dichloro-[1,3,5]triazin-2-ylamino)-ethyl]-benzenesulfonamide::CHEMBL187274

SMILES: NS(=O)(=O)c1ccc(CCNc2nc(Cl)nc(Cl)n2)cc1

InChI Key: InChIKey=YJRCEYRKXRXPCA-UHFFFAOYSA-N

Data: 8 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50153973   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Carbonic Anhydrase XIV (Homo sapiens (Human))	BDBM50153973 (4-[2-(4,6-Dichloro-[1,3,5]triazin-2-ylamino)-ethyl...) Show SMILES NS(=O)(=O)c1ccc(CCNc2nc(Cl)nc(Cl)n2)cc1 Show InChI InChI=1S/C11H11Cl2N5O2S/c12-9-16-10(13)18-11(17-9)15-6-5-7-1-3-8(4-2-7)21(14,19)20/h1-4H,5-6H2,(H2,14,19,20)(H,15,16,17,18)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	15.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration method				Bioorg Med Chem 19: 3105-19 (2011) Article DOI: 10.1016/j.bmc.2011.04.005 BindingDB Entry DOI: 10.7270/Q2FF3SQ6
					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50153973 (4-[2-(4,6-Dichloro-[1,3,5]triazin-2-ylamino)-ethyl...) Show SMILES NS(=O)(=O)c1ccc(CCNc2nc(Cl)nc(Cl)n2)cc1 Show InChI InChI=1S/C11H11Cl2N5O2S/c12-9-16-10(13)18-11(17-9)15-6-5-7-1-3-8(4-2-7)21(14,19)20/h1-4H,5-6H2,(H2,14,19,20)(H,15,16,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibitory activity against human carbonic anhydrase II expressed in Escherichia coli BL21				Bioorg Med Chem Lett 14: 5427-33 (2004) Article DOI: 10.1016/j.bmcl.2004.07.087 BindingDB Entry DOI: 10.7270/Q2XD12DQ
					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50153973 (4-[2-(4,6-Dichloro-[1,3,5]triazin-2-ylamino)-ethyl...) Show SMILES NS(=O)(=O)c1ccc(CCNc2nc(Cl)nc(Cl)n2)cc1 Show InChI InChI=1S/C11H11Cl2N5O2S/c12-9-16-10(13)18-11(17-9)15-6-5-7-1-3-8(4-2-7)21(14,19)20/h1-4H,5-6H2,(H2,14,19,20)(H,15,16,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration method				Bioorg Med Chem 19: 3105-19 (2011) Article DOI: 10.1016/j.bmc.2011.04.005 BindingDB Entry DOI: 10.7270/Q2FF3SQ6
					More data for this Ligand-Target Pair
Carbonic anhydrase 12 (Homo sapiens (Human))	BDBM50153973 (4-[2-(4,6-Dichloro-[1,3,5]triazin-2-ylamino)-ethyl...) Show SMILES NS(=O)(=O)c1ccc(CCNc2nc(Cl)nc(Cl)n2)cc1 Show InChI InChI=1S/C11H11Cl2N5O2S/c12-9-16-10(13)18-11(17-9)15-6-5-7-1-3-8(4-2-7)21(14,19)20/h1-4H,5-6H2,(H2,14,19,20)(H,15,16,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	43.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration method				Bioorg Med Chem 19: 3105-19 (2011) Article DOI: 10.1016/j.bmc.2011.04.005 BindingDB Entry DOI: 10.7270/Q2FF3SQ6
					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM50153973 (4-[2-(4,6-Dichloro-[1,3,5]triazin-2-ylamino)-ethyl...) Show SMILES NS(=O)(=O)c1ccc(CCNc2nc(Cl)nc(Cl)n2)cc1 Show InChI InChI=1S/C11H11Cl2N5O2S/c12-9-16-10(13)18-11(17-9)15-6-5-7-1-3-8(4-2-7)21(14,19)20/h1-4H,5-6H2,(H2,14,19,20)(H,15,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	75	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration method				Bioorg Med Chem 19: 3105-19 (2011) Article DOI: 10.1016/j.bmc.2011.04.005 BindingDB Entry DOI: 10.7270/Q2FF3SQ6
					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM50153973 (4-[2-(4,6-Dichloro-[1,3,5]triazin-2-ylamino)-ethyl...) Show SMILES NS(=O)(=O)c1ccc(CCNc2nc(Cl)nc(Cl)n2)cc1 Show InChI InChI=1S/C11H11Cl2N5O2S/c12-9-16-10(13)18-11(17-9)15-6-5-7-1-3-8(4-2-7)21(14,19)20/h1-4H,5-6H2,(H2,14,19,20)(H,15,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	75	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibitory activity against human carbonic anhydrase I expressed in Escherichia coli BL21				Bioorg Med Chem Lett 14: 5427-33 (2004) Article DOI: 10.1016/j.bmcl.2004.07.087 BindingDB Entry DOI: 10.7270/Q2XD12DQ
					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM50153973 (4-[2-(4,6-Dichloro-[1,3,5]triazin-2-ylamino)-ethyl...) Show SMILES NS(=O)(=O)c1ccc(CCNc2nc(Cl)nc(Cl)n2)cc1 Show InChI InChI=1S/C11H11Cl2N5O2S/c12-9-16-10(13)18-11(17-9)15-6-5-7-1-3-8(4-2-7)21(14,19)20/h1-4H,5-6H2,(H2,14,19,20)(H,15,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	138	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration method				Bioorg Med Chem 19: 3105-19 (2011) Article DOI: 10.1016/j.bmc.2011.04.005 BindingDB Entry DOI: 10.7270/Q2FF3SQ6
					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM50153973 (4-[2-(4,6-Dichloro-[1,3,5]triazin-2-ylamino)-ethyl...) Show SMILES NS(=O)(=O)c1ccc(CCNc2nc(Cl)nc(Cl)n2)cc1 Show InChI InChI=1S/C11H11Cl2N5O2S/c12-9-16-10(13)18-11(17-9)15-6-5-7-1-3-8(4-2-7)21(14,19)20/h1-4H,5-6H2,(H2,14,19,20)(H,15,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	138	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibitory activity against human carbonic anhydrase IX expressed in Escherichia coli BL21				Bioorg Med Chem Lett 14: 5427-33 (2004) Article DOI: 10.1016/j.bmcl.2004.07.087 BindingDB Entry DOI: 10.7270/Q2XD12DQ
					More data for this Ligand-Target Pair