BDBM50154442 2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-carboxylic acid::CHEMBL188448

SMILES: OC(=O)c1nc([nH]c(=O)c1O)-c1ccc(Cl)cc1

InChI Key: InChIKey=XNDKQQKHTBDWNQ-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50154442   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatitis C virus NS5B RNA-dependent RNA polymerase (Hepatitis C virus)	BDBM50154442 (2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-car...) Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C11H7ClN2O4/c12-6-3-1-5(2-4-6)9-13-7(11(17)18)8(15)10(16)14-9/h1-4,15H,(H,17,18)(H,13,14,16)	UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Italy. Vinc Curated by ChEMBL					Assay Description Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mg2+ is determined				J Med Chem 47: 5336-9 (2004) Article DOI: 10.1021/jm0494669 BindingDB Entry DOI: 10.7270/Q2G1609M
					More data for this Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase (Hepatitis C virus)	BDBM50154442 (2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-car...) Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C11H7ClN2O4/c12-6-3-1-5(2-4-6)9-13-7(11(17)18)8(15)10(16)14-9/h1-4,15H,(H,17,18)(H,13,14,16)	UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Italy. Vinc Curated by ChEMBL					Assay Description Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mn2+ is determined				J Med Chem 47: 5336-9 (2004) Article DOI: 10.1021/jm0494669 BindingDB Entry DOI: 10.7270/Q2G1609M
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50154442 (2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-car...) Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C11H7ClN2O4/c12-6-3-1-5(2-4-6)9-13-7(11(17)18)8(15)10(16)14-9/h1-4,15H,(H,17,18)(H,13,14,16)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Italy. Vinc Curated by ChEMBL					Assay Description Inhibitory concentration required to inhibit HIV-integrase is determined				J Med Chem 47: 5336-9 (2004) Article DOI: 10.1021/jm0494669 BindingDB Entry DOI: 10.7270/Q2G1609M
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50154442 (2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-car...) Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C11H7ClN2O4/c12-6-3-1-5(2-4-6)9-13-7(11(17)18)8(15)10(16)14-9/h1-4,15H,(H,17,18)(H,13,14,16)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase p66/p51 polymerase using PPT57 DNA/Cy5-labeled PPT24 as template/primer preincubated for 10 mins followed by...				Bioorg Med Chem 26: 1713-1726 (2018) Article DOI: 10.1016/j.bmc.2018.02.017 BindingDB Entry DOI: 10.7270/Q270842C
					More data for this Ligand-Target Pair
DNA polymerase I (Escherichia coli (strain K12))	BDBM50154442 (2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-car...) Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C11H7ClN2O4/c12-6-3-1-5(2-4-6)9-13-7(11(17)18)8(15)10(16)14-9/h1-4,15H,(H,17,18)(H,13,14,16)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Italy. Vinc Curated by ChEMBL					Assay Description Inhibitory concentration required to inhibit Klenow DNA-dependent DNA polymerase				J Med Chem 47: 5336-9 (2004) Article DOI: 10.1021/jm0494669 BindingDB Entry DOI: 10.7270/Q2G1609M
					More data for this Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase (Hepatitis C virus)	BDBM50154442 (2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-car...) Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C11H7ClN2O4/c12-6-3-1-5(2-4-6)9-13-7(11(17)18)8(15)10(16)14-9/h1-4,15H,(H,17,18)(H,13,14,16)	UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Inhibition of HCV NS5B Cdelta55 RNA dependent RNA polymerase expressed in Escherichia coli assessed as reduction in [3H]UTP incorporation using poly(...				Bioorg Med Chem 26: 1713-1726 (2018) Article DOI: 10.1016/j.bmc.2018.02.017 BindingDB Entry DOI: 10.7270/Q270842C
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50154442 (2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-car...) Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C11H7ClN2O4/c12-6-3-1-5(2-4-6)9-13-7(11(17)18)8(15)10(16)14-9/h1-4,15H,(H,17,18)(H,13,14,16)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase				Bioorg Med Chem 26: 1713-1726 (2018) Article DOI: 10.1016/j.bmc.2018.02.017 BindingDB Entry DOI: 10.7270/Q270842C
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50154442 (2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-car...) Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C11H7ClN2O4/c12-6-3-1-5(2-4-6)9-13-7(11(17)18)8(15)10(16)14-9/h1-4,15H,(H,17,18)(H,13,14,16)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Italy. Vinc Curated by ChEMBL					Assay Description Inhibitory concentration required to inhibit HIV-RT is determined				J Med Chem 47: 5336-9 (2004) Article DOI: 10.1021/jm0494669 BindingDB Entry DOI: 10.7270/Q2G1609M
					More data for this Ligand-Target Pair