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BDBM50154491 5-Acetyl-3-(4-bromo-benzyl)-1-(3,5-dichloro-phenyl)-3-methyl-1H-imidazo[1,2-a]imidazol-2-one::CHEMBL372268

SMILES: CC(=O)c1cnc2N(C(=O)C(C)(Cc3ccc(Br)cc3)n12)c1cc(Cl)cc(Cl)c1

InChI Key: InChIKey=SVCPLCNUNAMBAM-UHFFFAOYSA-N

Data: 1 Kd

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50154491   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Integrin beta-2/Leukocyte adhesion glycoprotein LFA-1 alpha


(Homo sapiens (Human))
BDBM50154491
PNG
(5-Acetyl-3-(4-bromo-benzyl)-1-(3,5-dichloro-phenyl...)
Show SMILES CC(=O)c1cnc2N(C(=O)C(C)(Cc3ccc(Br)cc3)n12)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C21H16BrCl2N3O2/c1-12(28)18-11-25-20-26(17-8-15(23)7-16(24)9-17)19(29)21(2,27(18)20)10-13-3-5-14(22)6-4-13/h3-9,11H,10H2,1-2H3
PDB

UniProtKB/SwissProt

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antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 240n/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Dissociation constant for human Lymphocyte function associated antigen 1 in LFA-1/ICAM-1 binding assay


J Med Chem 47: 5356-66 (2004)


Article DOI: 10.1021/jm049657b
BindingDB Entry DOI: 10.7270/Q2B857MB
More data for this
Ligand-Target Pair