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BDBM50154499 3-(4-Bromo-benzyl)-1-(3,5-dichloro-phenyl)-3,5-dimethyl-1H-imidazo[1,2-a]imidazol-2-one::CHEMBL188614

SMILES: Cc1cnc2N(C(=O)C(C)(Cc3ccc(Br)cc3)n12)c1cc(Cl)cc(Cl)c1

InChI Key: InChIKey=JCZHZSQAEMZHAT-UHFFFAOYSA-N

Data: 1 Kd

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50154499   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Integrin beta-2/Leukocyte adhesion glycoprotein LFA-1 alpha


(Homo sapiens (Human))
BDBM50154499
PNG
(3-(4-Bromo-benzyl)-1-(3,5-dichloro-phenyl)-3,5-dim...)
Show SMILES Cc1cnc2N(C(=O)C(C)(Cc3ccc(Br)cc3)n12)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C20H16BrCl2N3O/c1-12-11-24-19-25(17-8-15(22)7-16(23)9-17)18(27)20(2,26(12)19)10-13-3-5-14(21)6-4-13/h3-9,11H,10H2,1-2H3
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/a 340n/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Dissociation constant for human Lymphocyte function associated antigen 1 in LFA-1/ICAM-1 binding assay


J Med Chem 47: 5356-66 (2004)


Article DOI: 10.1021/jm049657b
BindingDB Entry DOI: 10.7270/Q2B857MB
More data for this
Ligand-Target Pair