BDBM50154571 1-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-2,2-diphenyl-ethylamine::CHEMBL281940
SMILES: NC(COCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(c1ccccc1)c1ccccc1
InChI Key: InChIKey=VSYVBQKQDBKTBD-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Neurokinin 1 receptor (Homo sapiens (Human)) | BDBM50154571 (1-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-2,2-di...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 10.7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells | Bioorg Med Chem Lett 5: 1345-1350 (1995) Article DOI: 10.1016/0960-894X(95)00220-N BindingDB Entry DOI: 10.7270/Q2416X13 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neurokinin 1 receptor (Homo sapiens (Human)) | BDBM50154571 (1-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-2,2-di...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 10.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps-Universit£t Marburg Curated by ChEMBL | Assay Description Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells | J Med Chem 47: 5381-92 (2004) Article DOI: 10.1021/jm0311487 BindingDB Entry DOI: 10.7270/Q2MG7Q8Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neurokinin 1 receptor (Homo sapiens (Human)) | BDBM50154571 (1-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-2,2-di...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 10.7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity of the compound towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P | Bioorg Med Chem Lett 4: 1903-1908 (1994) Article DOI: 10.1016/S0960-894X(01)80531-X BindingDB Entry DOI: 10.7270/Q2NK3DZ1 | |||||||||||
More data for this Ligand-Target Pair |