null

SMILES: Cc1cc(cc(C)c1C)-c1c(OCCC2COCCN2)c2cc(C(=O)Nc3cnsn3)c(Cl)cc2[nH]c1=O

InChI Key: InChIKey=XPTSNEGNQIBUPL-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50155356   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50155356 (7-Chloro-4-(2-morpholin-3-yl-ethoxy)-2-oxo-3-(3,4,...) Show SMILES Cc1cc(cc(C)c1C)-c1c(OCCC2COCCN2)c2cc(C(=O)Nc3cnsn3)c(Cl)cc2[nH]c1=O Show InChI InChI=1S/C27H28ClN5O4S/c1-14-8-17(9-15(2)16(14)3)24-25(37-6-4-18-13-36-7-5-29-18)20-10-19(21(28)11-22(20)31-27(24)35)26(34)32-23-12-30-38-33-23/h8-12,18,29H,4-7,13H2,1-3H3,(H,31,35)(H,32,33,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards human gonadotropin releasing hormone receptor expressed in CHO cells was determined by using [125I]-buserelin as radioligand				Bioorg Med Chem Lett 14: 5599-603 (2004) Article DOI: 10.1016/j.bmcl.2004.08.056 BindingDB Entry DOI: 10.7270/Q20V8C8D
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50155356 (7-Chloro-4-(2-morpholin-3-yl-ethoxy)-2-oxo-3-(3,4,...) Show SMILES Cc1cc(cc(C)c1C)-c1c(OCCC2COCCN2)c2cc(C(=O)Nc3cnsn3)c(Cl)cc2[nH]c1=O Show InChI InChI=1S/C27H28ClN5O4S/c1-14-8-17(9-15(2)16(14)3)24-25(37-6-4-18-13-36-7-5-29-18)20-10-19(21(28)11-22(20)31-27(24)35)26(34)32-23-12-30-38-33-23/h8-12,18,29H,4-7,13H2,1-3H3,(H,31,35)(H,32,33,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells expressing GnRH receptor				Bioorg Med Chem Lett 14: 5599-603 (2004) Article DOI: 10.1016/j.bmcl.2004.08.056 BindingDB Entry DOI: 10.7270/Q20V8C8D
					More data for this Ligand-Target Pair