BindingDB PrimarySearch

BDBM50155833 3-[4-(2,4-Bis-trifluoromethyl-benzyloxy)-3-methoxy-phenyl]-2-cyano-N-(5-trifluoromethyl-[1,3,4]thiadiazol-2-yl)-acrylamide::CHEMBL189753

SMILES: COc1cc(\C=C(/C#N)C(=O)Nc2nnc(s2)C(F)(F)F)ccc1OCc1ccc(cc1C(F)(F)F)C(F)(F)F

InChI Key: InChIKey=HQFNFOOGGLSBBT-AWNIVKPZSA-N

Data: 6 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50155833
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Estrogen-related receptor alpha (Homo sapiens (Human))	BDBM50155833 (3-[4-(2,4-Bis-trifluoromethyl-benzyloxy)-3-methoxy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
X-Ceptor Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of estrogen-related receptor alpha Gal4 activity				J Med Chem 47: 5593-6 (2004) Article DOI: 10.1021/jm049334f BindingDB Entry DOI: 10.7270/Q2959H16
X-Ceptor Therapeutics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen-related receptor alpha (Homo sapiens (Human))	BDBM50155833 (3-[4-(2,4-Bis-trifluoromethyl-benzyloxy)-3-methoxy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inverse agonist activity at GAL4-fused ERRalpha (unknown origin) transfected in african green monkey CV1 cells after 24 hrs by luciferase reporter ge...				J Med Chem 56: 4631-40 (2013) Article DOI: 10.1021/jm4003928 BindingDB Entry DOI: 10.7270/Q2GX4CZW
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor/Steroid hormone receptor ERR1 (Homo sapiens (Human))	BDBM50155833 (3-[4-(2,4-Bis-trifluoromethyl-benzyloxy)-3-methoxy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Inverse agonist activity at CMX-gal4-fused ERRgamma (unknown origin) transfected in (African Green monkey CV1 cells incubated for 20 hrs by luciferas...				ACS Med Chem Lett 10: 767-772 (2019) Article DOI: 10.1021/acsmedchemlett.9b00025
Jinan University Curated by ChEMBL					More data for this Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor/Steroid hormone receptor ERR1 (Homo sapiens (Human))	BDBM50155833 (3-[4-(2,4-Bis-trifluoromethyl-benzyloxy)-3-methoxy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Qilu University of Technology Curated by ChEMBL					Assay Description Inverse agonist activity at GAL4-DNA binding domain-fused human ERRalpha ligand binding domain expressed in HEK293 cells assessed as inhibition of tr...				Eur J Med Chem 136: 457-467 (2017) Article DOI: 10.1016/j.ejmech.2017.04.050 BindingDB Entry DOI: 10.7270/Q2C82CTV
Qilu University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
von Hippel-Lindau disease tumor suppressor/Steroid hormone receptor ERR1 (Homo sapiens (Human))	BDBM50155833 (3-[4-(2,4-Bis-trifluoromethyl-benzyloxy)-3-methoxy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Binding affinity to GST-tagged ERRalpha-LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assay				ACS Med Chem Lett 10: 767-772 (2019) Article DOI: 10.1021/acsmedchemlett.9b00025
Jinan University Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen-related receptor alpha (Homo sapiens (Human))	BDBM50155833 (3-[4-(2,4-Bis-trifluoromethyl-benzyloxy)-3-methoxy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Antagonist activity at ERRalpha LBD expressed in HEK293 cells assessed as Gal4-SRC2 interaction by two hybrid luciferase reporter gene assay				J Med Chem 54: 788-808 (2012) Article DOI: 10.1021/jm101063h BindingDB Entry DOI: 10.7270/Q208668Q
					More data for this Ligand-Target Pair