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SMILES: CCN(C(C)C)c1cc(C)nc2N(CC(=O)Nc12)c1cc(F)c(OC)cc1Cl

InChI Key: InChIKey=DZXRTFDRCBHMEB-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50155973   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50155973
PNG
(4-(2-Chloro-5-fluoro-4-methoxy-phenyl)-8-(ethyl-is...)
Show SMILES CCN(C(C)C)c1cc(C)nc2N(CC(=O)Nc12)c1cc(F)c(OC)cc1Cl
Show InChI InChI=1S/C20H24ClFN4O2/c1-6-25(11(2)3)16-7-12(4)23-20-19(16)24-18(27)10-26(20)15-9-14(22)17(28-5)8-13(15)21/h7-9,11H,6,10H2,1-5H3,(H,24,27)
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Article
PubMed
n/an/a 1.5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1

J Med Chem 47: 5783-90 (2004)


Article DOI: 10.1021/jm049737f
BindingDB Entry DOI: 10.7270/Q2S75FT6
More data for this
Ligand-Target Pair