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SMILES: CCCN(CCC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(cc1Cl)C#N

InChI Key: InChIKey=UAXGEDSQRRKJGF-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50155975   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50155975
PNG
(3-Chloro-4-(8-dipropylamino-6-methyl-2-oxo-2,3-dih...)
Show SMILES CCCN(CCC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(cc1Cl)C#N
Show InChI InChI=1S/C21H24ClN5O/c1-4-8-26(9-5-2)18-10-14(3)24-21-20(18)25-19(28)13-27(21)17-7-6-15(12-23)11-16(17)22/h6-7,10-11H,4-5,8-9,13H2,1-3H3,(H,25,28)
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Article
PubMed
n/an/a 1.20n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1

J Med Chem 47: 5783-90 (2004)


Article DOI: 10.1021/jm049737f
BindingDB Entry DOI: 10.7270/Q2S75FT6
More data for this
Ligand-Target Pair