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SMILES: CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccccc1Br

InChI Key: InChIKey=SNAFYADXBXWJBH-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50155981   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50155981
PNG
(4-(2-Bromo-phenyl)-8-(butyl-ethyl-amino)-6-methyl-...)
Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccccc1Br
Show InChI InChI=1S/C20H25BrN4O/c1-4-6-11-24(5-2)17-12-14(3)22-20-19(17)23-18(26)13-25(20)16-10-8-7-9-15(16)21/h7-10,12H,4-6,11,13H2,1-3H3,(H,23,26)
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n/an/a 7.10n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1

J Med Chem 47: 5783-90 (2004)


Article DOI: 10.1021/jm049737f
BindingDB Entry DOI: 10.7270/Q2S75FT6
More data for this
Ligand-Target Pair