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BDBM50156118 CHEMBL3785327

SMILES: Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2[nH]c(=O)[nH]c2c1

InChI Key: InChIKey=VRLSARGDMZKGFM-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50156118   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Bromodomain-containing protein 4


(Homo sapiens (Human))		BDBM50156118
PNG
(CHEMBL3785327)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2[nH]c(=O)[nH]c2c1 |(2.99,-4.33,;2.74,-5.54,;3.77,-6.69,;3,-8.03,;1.49,-7.71,;.57,-8.53,;1.35,-6.18,;.01,-5.41,;.02,-3.87,;-1.33,-3.08,;-1.33,-1.54,;-2.69,-.77,;-3.75,-1.39,;-2.69,.77,;-1.33,1.54,;,.77,;1.33,1.54,;2.67,.77,;2.67,-.77,;1.33,-1.54,;,-.77,;-2.66,-3.87,;-4.12,-3.39,;-5.03,-4.65,;-6.26,-4.65,;-4.13,-5.87,;-2.67,-5.4,;-1.34,-6.19,)|
Show InChI InChI=1S/C22H18N4O2/c1-11-6-7-17-15(5-4-8-23-17)19(11)16-9-14(20-12(2)26-28-13(20)3)10-18-21(16)25-22(27)24-18/h4-10H,1-3H3,(H2,24,25,27)
PDB

KEGG

UniProtKB/SwissProt

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antibodypedia
GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a<14n/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Displacement of biotinylated tetra-acetylated histone H4 from his-tagged BRD4 bromodomain1 (unknown origin) incubated for 60 mins by Alphascreen assa...

J Med Chem 59: 1271-98 (2016)


BindingDB Entry DOI: 10.7270/Q2X92D6H
More data for this
Ligand-Target Pair