BDBM50156313 4-[3-(3-{2-[1-(2-Methoxy-phenyl)-piperidin-4-ylamino]-ethyl}-ureido)-phenyl]-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester::CHEMBL187555
SMILES: COC(=O)C1C(C(C(=O)OC)=C(C)N=C1C)c1cccc(NC(=O)NCCNC2CCN(CC2)c2ccccc2OC)c1
InChI Key: InChIKey=GTAINOFJBBDHRA-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neuropeptide Y receptor type 1 (Homo sapiens (Human)) | BDBM50156313 (4-[3-(3-{2-[1-(2-Methoxy-phenyl)-piperidin-4-ylami...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Antagonist activity towards Neuropeptide Y receptor type 1 | Bioorg Med Chem Lett 14: 5975-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.005 BindingDB Entry DOI: 10.7270/Q2765DTG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuropeptide Y receptor type 1 (Homo sapiens (Human)) | BDBM50156313 (4-[3-(3-{2-[1-(2-Methoxy-phenyl)-piperidin-4-ylami...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of binding of [125I]-PYY to membranes of SK-N-MC cells expressing the human Y1 receptors | Bioorg Med Chem Lett 14: 5975-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.005 BindingDB Entry DOI: 10.7270/Q2765DTG | |||||||||||
More data for this Ligand-Target Pair |