BDBM50156377 CHEMBL3785425

SMILES: Nc1ncnc2n(cc(-c3cc(F)cc(OC[C@H]4CCCO4)c3)c12)[C@@H]1C[C@H](CN2CC[S+]([O-])CC2)C1

InChI Key: InChIKey=ZGWCTFPWFCDXAF-JRGCBEDISA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50156377   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50156377 (CHEMBL3785425) Show SMILES Nc1ncnc2n(cc(-c3cc(F)cc(OC[C@H]4CCCO4)c3)c12)[C@@H]1C[C@H](CN2CC[S+]([O-])CC2)C1 |r,wU:17.16,wD:24.27,26.30,(-1.03,2.79,;-1.03,1.55,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;1.76,-1.24,;2.66,.02,;1.76,1.24,;2.23,2.7,;3.76,2.91,;4.33,4.34,;5.55,4.52,;3.38,5.55,;1.86,5.34,;.91,6.55,;1.49,7.98,;.54,9.2,;-.98,9.12,;-1.51,10.57,;-.3,11.52,;.98,10.66,;1.29,3.91,;.3,.77,;2.24,-2.7,;3.54,-3.45,;2.74,-4.76,;3.1,-6.25,;4.58,-6.69,;4.94,-8.18,;6.42,-8.61,;7.53,-7.55,;8.72,-7.89,;7.17,-6.05,;5.69,-5.62,;1.42,-3.96,)| Show InChI InChI=1S/C26H32FN5O3S/c27-19-10-18(11-22(12-19)35-15-21-2-1-5-34-21)23-14-32(26-24(23)25(28)29-16-30-26)20-8-17(9-20)13-31-3-6-36(33)7-4-31/h10-12,14,16-17,20-21H,1-9,13,15H2,(H2,28,29,30)/t17-,20+,21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of IGF-1 receptor (unknown origin) in presence of [gamma33P]ATP				Bioorg Med Chem Lett 26: 2057-64 (2016) BindingDB Entry DOI: 10.7270/Q29K4D4J
					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50156377 (CHEMBL3785425) Show SMILES Nc1ncnc2n(cc(-c3cc(F)cc(OC[C@H]4CCCO4)c3)c12)[C@@H]1C[C@H](CN2CC[S+]([O-])CC2)C1 |r,wU:17.16,wD:24.27,26.30,(-1.03,2.79,;-1.03,1.55,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;1.76,-1.24,;2.66,.02,;1.76,1.24,;2.23,2.7,;3.76,2.91,;4.33,4.34,;5.55,4.52,;3.38,5.55,;1.86,5.34,;.91,6.55,;1.49,7.98,;.54,9.2,;-.98,9.12,;-1.51,10.57,;-.3,11.52,;.98,10.66,;1.29,3.91,;.3,.77,;2.24,-2.7,;3.54,-3.45,;2.74,-4.76,;3.1,-6.25,;4.58,-6.69,;4.94,-8.18,;6.42,-8.61,;7.53,-7.55,;8.72,-7.89,;7.17,-6.05,;5.69,-5.62,;1.42,-3.96,)| Show InChI InChI=1S/C26H32FN5O3S/c27-19-10-18(11-22(12-19)35-15-21-2-1-5-34-21)23-14-32(26-24(23)25(28)29-16-30-26)20-8-17(9-20)13-31-3-6-36(33)7-4-31/h10-12,14,16-17,20-21H,1-9,13,15H2,(H2,28,29,30)/t17-,20+,21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of full length IGF-1 receptor (unknown origin) autophosphorylation transfected in HEK293 cells pretreated for 60 mins followed by IGF-1 st...				Bioorg Med Chem Lett 26: 2057-64 (2016) BindingDB Entry DOI: 10.7270/Q29K4D4J
					More data for this Ligand-Target Pair