BDBM50156669 4,5,6,7-TETRABROMO-BENZIMIDAZOLE::4,5,6,7-tetrabromo-1H-benzimidazole::4,5,6,7-tetrabromo-1H-benzo[d]imidazole::4,5,6,7-tetrabromo-1Hbenzimidazole (1)::4,5,6,7-tetrabromobenzimidazole::CHEMBL373937

SMILES: Brc1c(Br)c(Br)c2[nH]cnc2c1Br

InChI Key: InChIKey=LOEIRDBRYBHAJB-UHFFFAOYSA-N

Data: 8 KI  4 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50156669   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Casein kinase II subunit alpha (Homo sapiens (Human))	BDBM50156669 (4,5,6,7-TETRABROMO-BENZIMIDAZOLE | 4,5,6,7-tetrabr...) Show SMILES Brc1c(Br)c(Br)c2[nH]cnc2c1Br Show InChI InChI=1S/C7H2Br4N2/c8-2-3(9)5(11)7-6(4(2)10)12-1-13-7/h1H,(H,12,13)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of CK2alpha in human PLC1 cells using (Arg)3(Glu)3Thr(Glu)3 as substrate after 24 hrs in presence of [32P]gammaGTP				Eur J Med Chem 181: (2019) Article DOI: 10.1016/j.ejmech.2019.111581
					More data for this Ligand-Target Pair
Casein kinase II subunit alpha (Homo sapiens (Human))	BDBM50156669 (4,5,6,7-TETRABROMO-BENZIMIDAZOLE | 4,5,6,7-tetrabr...) Show SMILES Brc1c(Br)c(Br)c2[nH]cnc2c1Br Show InChI InChI=1S/C7H2Br4N2/c8-2-3(9)5(11)7-6(4(2)10)12-1-13-7/h1H,(H,12,13)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	45	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Colorado State University Curated by ChEMBL					Assay Description Inhibition of human wild type CK2alpha				J Med Chem 59: 1655-70 (2016) BindingDB Entry DOI: 10.7270/Q24T6M70
					More data for this Ligand-Target Pair
Casein kinase II alpha' (Homo sapiens (Human))	BDBM50156669 (4,5,6,7-TETRABROMO-BENZIMIDAZOLE | 4,5,6,7-tetrabr...) Show SMILES Brc1c(Br)c(Br)c2[nH]cnc2c1Br Show InChI InChI=1S/C7H2Br4N2/c8-2-3(9)5(11)7-6(4(2)10)12-1-13-7/h1H,(H,12,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The John Paul II Catholic University of Lublin Curated by ChEMBL					Assay Description Inhibition of human CK2 alpha' catalytic subunit expressed in Escherichia coli BL21 (DE3) assessed as [33P]gamma-ATP incorporation into P2B substrate...				Eur J Med Chem 47: 345-50 (2012) Article DOI: 10.1016/j.ejmech.2011.11.002 BindingDB Entry DOI: 10.7270/Q2377944
					More data for this Ligand-Target Pair
Casein kinase II subunit alpha (Homo sapiens (Human))	BDBM50156669 (4,5,6,7-TETRABROMO-BENZIMIDAZOLE | 4,5,6,7-tetrabr...) Show SMILES Brc1c(Br)c(Br)c2[nH]cnc2c1Br Show InChI InChI=1S/C7H2Br4N2/c8-2-3(9)5(11)7-6(4(2)10)12-1-13-7/h1H,(H,12,13)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	315	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The John Paul II Catholic University of Lublin Curated by ChEMBL					Assay Description Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BL21 (DE3) assessed as [33P]gamma-ATP incorporation into RRRADDSDDDDD s...				Eur J Med Chem 47: 345-50 (2012) Article DOI: 10.1016/j.ejmech.2011.11.002 BindingDB Entry DOI: 10.7270/Q2377944
					More data for this Ligand-Target Pair
Casein kinase II alpha' (Homo sapiens (Human))	BDBM50156669 (4,5,6,7-TETRABROMO-BENZIMIDAZOLE | 4,5,6,7-tetrabr...) Show SMILES Brc1c(Br)c(Br)c2[nH]cnc2c1Br Show InChI InChI=1S/C7H2Br4N2/c8-2-3(9)5(11)7-6(4(2)10)12-1-13-7/h1H,(H,12,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	343	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The John Paul II Catholic University of Lublin Curated by ChEMBL					Assay Description Inhibition of human CK2 alpha' catalytic subunit expressed in Escherichia coli BE21 (DE3) assessed as [33P]gamma-ATP incorporation into RRRADDSDDDDD ...				Eur J Med Chem 47: 345-50 (2012) Article DOI: 10.1016/j.ejmech.2011.11.002 BindingDB Entry DOI: 10.7270/Q2377944
					More data for this Ligand-Target Pair
Casein kinase II subunit alpha (Homo sapiens (Human))	BDBM50156669 (4,5,6,7-TETRABROMO-BENZIMIDAZOLE | 4,5,6,7-tetrabr...) Show SMILES Brc1c(Br)c(Br)c2[nH]cnc2c1Br Show InChI InChI=1S/C7H2Br4N2/c8-2-3(9)5(11)7-6(4(2)10)12-1-13-7/h1H,(H,12,13)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	462	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The John Paul II Catholic University of Lublin Curated by ChEMBL					Assay Description Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BE21 (DE3) assessed as [33P]gamma-ATP incorporation into P2B substrate ...				Eur J Med Chem 47: 345-50 (2012) Article DOI: 10.1016/j.ejmech.2011.11.002 BindingDB Entry DOI: 10.7270/Q2377944
					More data for this Ligand-Target Pair
Casein kinase II subunit alpha (Homo sapiens (Human))	BDBM50156669 (4,5,6,7-TETRABROMO-BENZIMIDAZOLE | 4,5,6,7-tetrabr...) Show SMILES Brc1c(Br)c(Br)c2[nH]cnc2c1Br Show InChI InChI=1S/C7H2Br4N2/c8-2-3(9)5(11)7-6(4(2)10)12-1-13-7/h1H,(H,12,13)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	680	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Warsaw University of Technology					Assay Description The activity of CK2α was tested using P81 filter isotopic assay, as it was described earlier [Łukowska-Chojnacka et al., Bioorg. Med. Chem....				Bioorg Chem 72: 1-10 (2017) Article DOI: 10.1016/j.bioorg.2017.02.017 BindingDB Entry DOI: 10.7270/Q2J10216
					More data for this Ligand-Target Pair
Casein kinase II subunit alpha (Homo sapiens (Human))	BDBM50156669 (4,5,6,7-TETRABROMO-BENZIMIDAZOLE | 4,5,6,7-tetrabr...) Show SMILES Brc1c(Br)c(Br)c2[nH]cnc2c1Br Show InChI InChI=1S/C7H2Br4N2/c8-2-3(9)5(11)7-6(4(2)10)12-1-13-7/h1H,(H,12,13)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	1.03E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Warsaw University of Technology Curated by ChEMBL					Assay Description Inhibition of recombinant human CK2alpha using RRRDDDSDDD substrate peptide by scintillation counter in presence of [32P]ATP				Bioorg Med Chem 24: 735-41 (2016) BindingDB Entry DOI: 10.7270/Q2571DV4
					More data for this Ligand-Target Pair
Ribosyldihydronicotinamide dehydrogenase [quinone] (Homo sapiens (Human))	BDBM50156669 (4,5,6,7-TETRABROMO-BENZIMIDAZOLE | 4,5,6,7-tetrabr...) Show SMILES Brc1c(Br)c(Br)c2[nH]cnc2c1Br Show InChI InChI=1S/C7H2Br4N2/c8-2-3(9)5(11)7-6(4(2)10)12-1-13-7/h1H,(H,12,13)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	79.4	n/a	n/a	n/a	n/a	n/a	n/a
University of Western Ontario					Assay Description To determine the IC50 value of each inhibitor, reactions were initiated by addition of 154 pM NQO2 to a reaction buffer containing 150 μM SCDP a...				Biochemistry 54: 47-59 (2015) Article DOI: 10.1021/bi500959t BindingDB Entry DOI: 10.7270/Q2BV7FC9
					More data for this Ligand-Target Pair				3D Structure (crystal)
Ribosyldihydronicotinamide dehydrogenase [quinone] (Homo sapiens (Human))	BDBM50156669 (4,5,6,7-TETRABROMO-BENZIMIDAZOLE | 4,5,6,7-tetrabr...) Show SMILES Brc1c(Br)c(Br)c2[nH]cnc2c1Br Show InChI InChI=1S/C7H2Br4N2/c8-2-3(9)5(11)7-6(4(2)10)12-1-13-7/h1H,(H,12,13)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	18.1	n/a	n/a	n/a	n/a	n/a
University of Western Ontario					Assay Description To assess direct binding of inhibitors to oxidized NQO2 (NQO2ox), fluorescence quenching of FAD was monitored with an excitation wavelength of 350 nm...				Biochemistry 54: 47-59 (2015) Article DOI: 10.1021/bi500959t BindingDB Entry DOI: 10.7270/Q2BV7FC9
					More data for this Ligand-Target Pair				3D Structure (crystal)
Casein kinase II subunit alpha (Homo sapiens (Human))	BDBM50156669 (4,5,6,7-TETRABROMO-BENZIMIDAZOLE | 4,5,6,7-tetrabr...) Show SMILES Brc1c(Br)c(Br)c2[nH]cnc2c1Br Show InChI InChI=1S/C7H2Br4N2/c8-2-3(9)5(11)7-6(4(2)10)12-1-13-7/h1H,(H,12,13)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Biochemistry and Biophysics Curated by ChEMBL					Assay Description Inhibition of human recombinant casein kinase 2 subunit alpha expressed in Escherichia coli BL21 (DE3) assessed as [32P] incorporation by liquid scin...				Bioorg Med Chem 17: 1573-8 (2009) Article DOI: 10.1016/j.bmc.2008.12.071 BindingDB Entry DOI: 10.7270/Q23J3CVZ
					More data for this Ligand-Target Pair
Casein kinase II subunit alpha (Homo sapiens (Human))	BDBM50156669 (4,5,6,7-TETRABROMO-BENZIMIDAZOLE | 4,5,6,7-tetrabr...) Show SMILES Brc1c(Br)c(Br)c2[nH]cnc2c1Br Show InChI InChI=1S/C7H2Br4N2/c8-2-3(9)5(11)7-6(4(2)10)12-1-13-7/h1H,(H,12,13)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
University of Tartu Curated by ChEMBL					Assay Description Displacement of 5-TAMRA-labeled ARC-1530 from CK2alpha (unknown origin) (1 to 335 residues) after 15 to 60 mins by luminescence assay				Bioorg Med Chem 26: 5062-5068 (2018) Article DOI: 10.1016/j.bmc.2018.09.003 BindingDB Entry DOI: 10.7270/Q26112V7
					More data for this Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A (Homo sapiens (Human))	BDBM50156669 (4,5,6,7-TETRABROMO-BENZIMIDAZOLE | 4,5,6,7-tetrabr...) Show SMILES Brc1c(Br)c(Br)c2[nH]cnc2c1Br Show InChI InChI=1S/C7H2Br4N2/c8-2-3(9)5(11)7-6(4(2)10)12-1-13-7/h1H,(H,12,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Inhibition of DYRK1A (unknown origin)				J Med Chem 61: 9791-9810 (2018) Article DOI: 10.1021/acs.jmedchem.8b00185 BindingDB Entry DOI: 10.7270/Q2H41V3Q
					More data for this Ligand-Target Pair