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BDBM50156869 2-{2-[4-(1-cyclopropylmethyl-1H-indol-3-yl)piperidin-1-yl]ethoxy}benzoic acid::CHEMBL375208

SMILES: OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(CC2CC2)c2ccccc12

InChI Key: InChIKey=VBXUDFDAMGGOQA-UHFFFAOYSA-N

Data: 2 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50156869   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50156869
PNG
(2-{2-[4-(1-cyclopropylmethyl-1H-indol-3-yl)piperid...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(CC2CC2)c2ccccc12
Show InChI InChI=1S/C26H30N2O3/c29-26(30)22-6-2-4-8-25(22)31-16-15-27-13-11-20(12-14-27)23-18-28(17-19-9-10-19)24-7-3-1-5-21(23)24/h1-8,18-20H,9-17H2,(H,29,30)
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UniProtKB/SwissProt

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GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50156869
PNG
(2-{2-[4-(1-cyclopropylmethyl-1H-indol-3-yl)piperid...)
Show SMILES OC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(CC2CC2)c2ccccc12
Show InChI InChI=1S/C26H30N2O3/c29-26(30)22-6-2-4-8-25(22)31-16-15-27-13-11-20(12-14-27)23-18-28(17-19-9-10-19)24-7-3-1-5-21(23)24/h1-8,18-20H,9-17H2,(H,29,30)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 140n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranes


J Med Chem 47: 6326-37 (2004)


Article DOI: 10.1021/jm0498203
BindingDB Entry DOI: 10.7270/Q2HM57XC
More data for this
Ligand-Target Pair