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BDBM50156929 CHEMBL3794079

SMILES: Cc1ccc(CN2CCO[C@H](CSc3ccccc3)C2)cc1C

InChI Key: InChIKey=PZYOBKWKADZRBF-TWYLJJHKNA-N

Data: 6 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50156929   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50156929
PNG
(CHEMBL3794079)
Show SMILES Cc1ccc(CN2CCO[C@H](CSc3ccccc3)C2)cc1C |r|
Show InChI InChI=1/C20H25NOS/c1-16-8-9-18(12-17(16)2)13-21-10-11-22-19(14-21)15-23-20-6-4-3-5-7-20/h3-9,12,19H,10-11,13-15H2,1-2H3/t19-/s2
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7.40n/an/an/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from human recombinant dopamine D4 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 26: 2481-8 (2016)


BindingDB Entry DOI: 10.7270/Q2G44S5M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50156929
PNG
(CHEMBL3794079)
Show SMILES Cc1ccc(CN2CCO[C@H](CSc3ccccc3)C2)cc1C |r|
Show InChI InChI=1/C20H25NOS/c1-16-8-9-18(12-17(16)2)13-21-10-11-22-19(14-21)15-23-20-6-4-3-5-7-20/h3-9,12,19H,10-11,13-15H2,1-2H3/t19-/s2
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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
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>1.00E+4n/an/an/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from human recombinant dopamine D2L receptor expressed in CHO cells


Bioorg Med Chem Lett 26: 2481-8 (2016)


BindingDB Entry DOI: 10.7270/Q2G44S5M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50156929
PNG
(CHEMBL3794079)
Show SMILES Cc1ccc(CN2CCO[C@H](CSc3ccccc3)C2)cc1C |r|
Show InChI InChI=1/C20H25NOS/c1-16-8-9-18(12-17(16)2)13-21-10-11-22-19(14-21)15-23-20-6-4-3-5-7-20/h3-9,12,19H,10-11,13-15H2,1-2H3/t19-/s2
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PC sid
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>1.00E+4n/an/an/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from human recombinant dopamine D2S receptor expressed in CHO cells


Bioorg Med Chem Lett 26: 2481-8 (2016)


BindingDB Entry DOI: 10.7270/Q2G44S5M
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50156929
PNG
(CHEMBL3794079)
Show SMILES Cc1ccc(CN2CCO[C@H](CSc3ccccc3)C2)cc1C |r|
Show InChI InChI=1/C20H25NOS/c1-16-8-9-18(12-17(16)2)13-21-10-11-22-19(14-21)15-23-20-6-4-3-5-7-20/h3-9,12,19H,10-11,13-15H2,1-2H3/t19-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Displacement of [3H]-SCH-23390 from human recombinant dopamine D5 receptor expressed in CHO cells


Bioorg Med Chem Lett 26: 2481-8 (2016)


BindingDB Entry DOI: 10.7270/Q2G44S5M
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50156929
PNG
(CHEMBL3794079)
Show SMILES Cc1ccc(CN2CCO[C@H](CSc3ccccc3)C2)cc1C |r|
Show InChI InChI=1/C20H25NOS/c1-16-8-9-18(12-17(16)2)13-21-10-11-22-19(14-21)15-23-20-6-4-3-5-7-20/h3-9,12,19H,10-11,13-15H2,1-2H3/t19-/s2
KEGG

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antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Displacement of [3H]-SCH-23390 from human recombinant dopamine D1 receptor expressed in CHO cells


Bioorg Med Chem Lett 26: 2481-8 (2016)


BindingDB Entry DOI: 10.7270/Q2G44S5M
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50156929
PNG
(CHEMBL3794079)
Show SMILES Cc1ccc(CN2CCO[C@H](CSc3ccccc3)C2)cc1C |r|
Show InChI InChI=1/C20H25NOS/c1-16-8-9-18(12-17(16)2)13-21-10-11-22-19(14-21)15-23-20-6-4-3-5-7-20/h3-9,12,19H,10-11,13-15H2,1-2H3/t19-/s2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from human recombinant dopamine D3 receptor expressed in CHO cells


Bioorg Med Chem Lett 26: 2481-8 (2016)


BindingDB Entry DOI: 10.7270/Q2G44S5M
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50156929
PNG
(CHEMBL3794079)
Show SMILES Cc1ccc(CN2CCO[C@H](CSc3ccccc3)C2)cc1C |r|
Show InChI InChI=1/C20H25NOS/c1-16-8-9-18(12-17(16)2)13-21-10-11-22-19(14-21)15-23-20-6-4-3-5-7-20/h3-9,12,19H,10-11,13-15H2,1-2H3/t19-/s2
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n/an/a 27n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Displacement of [3H]-Spiperone from human recombinant dopamine D4 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 26: 2481-8 (2016)


BindingDB Entry DOI: 10.7270/Q2G44S5M
More data for this
Ligand-Target Pair