BDBM50157309 CHEMBL3780320

SMILES: COc1ccccc1Nc1cc[nH]c(=O)c1C(=O)Nc1ccc(N2CCN(C)CC2)c(C)c1

InChI Key: InChIKey=JVBRYDUIZXYSDV-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50157309   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50157309 (CHEMBL3780320) Show SMILES COc1ccccc1Nc1cc[nH]c(=O)c1C(=O)Nc1ccc(N2CCN(C)CC2)c(C)c1 Show InChI InChI=1S/C25H29N5O3/c1-17-16-18(8-9-21(17)30-14-12-29(2)13-15-30)27-25(32)23-20(10-11-26-24(23)31)28-19-6-4-5-7-22(19)33-3/h4-11,16H,12-15H2,1-3H3,(H,27,32)(H2,26,28,31)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human EGFR catalytic domain (668 to 1210 residues) T790M/L858R double mutant using Fl-EEPLYWSFPAKKK-CONH2 peptide substrate preincubate...				ACS Med Chem Lett 7: 100-4 (2016) BindingDB Entry DOI: 10.7270/Q25T3NCC
					More data for this Ligand-Target Pair