BDBM50157364 CHEMBL3780955

SMILES: CN1CCN(CC1)c1ccc(NC(=O)c2c(Nc3ccccc3Cl)cc[nH]c2=O)cc1

InChI Key: InChIKey=FPVOGFVOUBMABC-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50157364   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50157364 (CHEMBL3780955) Show SMILES CN1CCN(CC1)c1ccc(NC(=O)c2c(Nc3ccccc3Cl)cc[nH]c2=O)cc1 Show InChI InChI=1S/C23H24ClN5O2/c1-28-12-14-29(15-13-28)17-8-6-16(7-9-17)26-23(31)21-20(10-11-25-22(21)30)27-19-5-3-2-4-18(19)24/h2-11H,12-15H2,1H3,(H,26,31)(H2,25,27,30)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	82	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human EGFR catalytic domain (668 to 1210 residues) T790M/L858R double mutant using Fl-EEPLYWSFPAKKK-CONH2 peptide substrate preincubate...				ACS Med Chem Lett 7: 100-4 (2016) BindingDB Entry DOI: 10.7270/Q25T3NCC
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50157364 (CHEMBL3780955) Show SMILES CN1CCN(CC1)c1ccc(NC(=O)c2c(Nc3ccccc3Cl)cc[nH]c2=O)cc1 Show InChI InChI=1S/C23H24ClN5O2/c1-28-12-14-29(15-13-28)17-8-6-16(7-9-17)26-23(31)21-20(10-11-25-22(21)30)27-19-5-3-2-4-18(19)24/h2-11H,12-15H2,1H3,(H,26,31)(H2,25,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.48E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human N-terminal GST-tagged EGFR catalytic domain (669 to 1210 residues) expressed in baculovirus expression system using Fl-EEPLYWSFPA...				ACS Med Chem Lett 7: 100-4 (2016) BindingDB Entry DOI: 10.7270/Q25T3NCC
					More data for this Ligand-Target Pair