BindingDB PrimarySearch

BDBM50157547 2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-4H-chromen-4-one::7,8,3',4'-tetrahydroxyflavone::CHEMBL222541

SMILES: Oc1ccc(cc1O)-c1cc(=O)c2ccc(O)c(O)c2o1

InChI Key: InChIKey=ARYCMKPCDNHQCL-UHFFFAOYSA-N

Data: 7 IC50

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50157547
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50157547 (2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-4H-chromen-4...) Show SMILES Oc1ccc(cc1O)-c1cc(=O)c2ccc(O)c(O)c2o1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
BU-Nerviano Medical Sciences Curated by ChEMBL					Assay Description Inhibition of human telomerase from HEK293 cell extracts by Flash-Plate assay				J Med Chem 47: 6466-75 (2004) Article DOI: 10.1021/jm040810b BindingDB Entry DOI: 10.7270/Q2P55N1R
BU-Nerviano Medical Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50157547 (2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-4H-chromen-4...) Show SMILES Oc1ccc(cc1O)-c1cc(=O)c2ccc(O)c(O)c2o1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Keimyung University Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 17: 1284-7 (2007) Article DOI: 10.1016/j.bmcl.2006.12.011 BindingDB Entry DOI: 10.7270/Q2BK1C0H
Keimyung University Curated by ChEMBL					More data for this Ligand-Target Pair
Polyphenol oxidase 2 (Agaricus bisporus (Common mushroom))	BDBM50157547 (2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-4H-chromen-4...) Show SMILES Oc1ccc(cc1O)-c1cc(=O)c2ccc(O)c(O)c2o1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Theoretical Medicine, Inc. Curated by ChEMBL					Assay Description Non-competitive inhibition of mushroom tyrosinase				Bioorg Med Chem 22: 6193-200 (2014) Article DOI: 10.1016/j.bmc.2014.08.027 BindingDB Entry DOI: 10.7270/Q2DV1MG2
Institute for Theoretical Medicine, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50157547 (2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-4H-chromen-4...) Show SMILES Oc1ccc(cc1O)-c1cc(=O)c2ccc(O)c(O)c2o1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	740	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of telomerase activity (unknown origin) in cell free system using sulforhodamine labeled primer measured after 30 mins by telomerase repea...				Eur J Med Chem 125: 117-129 (2017) BindingDB Entry DOI: 10.7270/Q2NS0X5V
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50157547 (2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-4H-chromen-4...) Show SMILES Oc1ccc(cc1O)-c1cc(=O)c2ccc(O)c(O)c2o1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction follo...				J Med Chem 55: 3678-86 (2012) Article DOI: 10.1021/jm201191d BindingDB Entry DOI: 10.7270/Q2DF6SB3
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50157547 (2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-4H-chromen-4...) Show SMILES Oc1ccc(cc1O)-c1cc(=O)c2ccc(O)c(O)c2o1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction by te...				J Med Chem 55: 3678-86 (2012) Article DOI: 10.1021/jm201191d BindingDB Entry DOI: 10.7270/Q2DF6SB3
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50157547 (2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-4H-chromen-4...) Show SMILES Oc1ccc(cc1O)-c1cc(=O)c2ccc(O)c(O)c2o1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of telomerase in human HEK293 cells by flashplate assay				J Med Chem 55: 3678-86 (2012) Article DOI: 10.1021/jm201191d BindingDB Entry DOI: 10.7270/Q2DF6SB3
University of California Curated by ChEMBL					More data for this Ligand-Target Pair