null

SMILES: CC(C)C[C@H](NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)OC(C)(C)C

InChI Key: InChIKey=AHNVCELUVSJVQG-IHZBLBIESA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50157590   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157590 ((S)-tert-butyl 2-((S)-2-(3-benzyl-3-((2R,3S)-3-(te...) Show SMILES CC(C)C[C@H](NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)OC(C)(C)C |r| Show InChI InChI=1S/C38H58N4O7/c1-25(2)21-30(33(44)41-32(26(3)4)34(45)48-37(5,6)7)39-35(46)42(23-28-19-15-12-16-20-28)24-31(43)29(22-27-17-13-11-14-18-27)40-36(47)49-38(8,9)10/h11-20,25-26,29-32,43H,21-24H2,1-10H3,(H,39,46)(H,40,47)(H,41,44)/t29-,30-,31+,32-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of gamma secretase in CHO cells expressing human APP after 24 hrs by ELISA				J Med Chem 47: 6485-9 (2004) Article DOI: 10.1021/jm049566e BindingDB Entry DOI: 10.7270/Q2MK6DP8
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157590 ((S)-tert-butyl 2-((S)-2-(3-benzyl-3-((2R,3S)-3-(te...) Show SMILES CC(C)C[C@H](NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)OC(C)(C)C |r| Show InChI InChI=1S/C38H58N4O7/c1-25(2)21-30(33(44)41-32(26(3)4)34(45)48-37(5,6)7)39-35(46)42(23-28-19-15-12-16-20-28)24-31(43)29(22-27-17-13-11-14-18-27)40-36(47)49-38(8,9)10/h11-20,25-26,29-32,43H,21-24H2,1-10H3,(H,39,46)(H,40,47)(H,41,44)/t29-,30-,31+,32-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of gamma secretase in CHO cells expressing human APP after 4 hrs by ELISA				J Med Chem 47: 6485-9 (2004) Article DOI: 10.1021/jm049566e BindingDB Entry DOI: 10.7270/Q2MK6DP8
					More data for this Ligand-Target Pair