null
SMILES: On1c(=O)[nH]c2sccc2c1=O
InChI Key: InChIKey=NNWNTVVLCCOLEQ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Flap endonuclease 1 (Homo sapiens (Human)) | BDBM50157832 (3-Hydroxy-4a,7a-dihydro-1H-thieno[2,3-d]pyrimidine...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.0250 | n/a | n/a | n/a | n/a | n/a | n/a |
Athersys, Inc. Curated by ChEMBL | Assay Description Inhibitory concentration against the Flap endonuclease-1 | Bioorg Med Chem Lett 15: 277-81 (2004) Article DOI: 10.1016/j.bmcl.2004.10.086 BindingDB Entry DOI: 10.7270/Q2HD7V46 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA excision repair protein ERCC-5 (Homo sapiens (Human)) | BDBM50157832 (3-Hydroxy-4a,7a-dihydro-1H-thieno[2,3-d]pyrimidine...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.101 | n/a | n/a | n/a | n/a | n/a | n/a |
Athersys, Inc. Curated by ChEMBL | Assay Description Inhibitory concentration against the xeroderma pigmentosum G | Bioorg Med Chem Lett 15: 277-81 (2004) Article DOI: 10.1016/j.bmcl.2004.10.086 BindingDB Entry DOI: 10.7270/Q2HD7V46 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Flap endonuclease 1 (Homo sapiens (Human)) | BDBM50157832 (3-Hydroxy-4a,7a-dihydro-1H-thieno[2,3-d]pyrimidine...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
MRC Technology Curated by ChEMBL | Assay Description Inhibition of FEN1 (unknown origin) | Bioorg Med Chem Lett 25: 4104-8 (2015) BindingDB Entry DOI: 10.7270/Q28S4RQ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50157832 (3-Hydroxy-4a,7a-dihydro-1H-thieno[2,3-d]pyrimidine...) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of HIV1 integrase pre-incubated for 10 mins before DNA substrate addition and measured after 30 mins | Eur J Med Chem 141: 149-161 (2017) Article DOI: 10.1016/j.ejmech.2017.09.054 BindingDB Entry DOI: 10.7270/Q2N58PW6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM50157832 (3-Hydroxy-4a,7a-dihydro-1H-thieno[2,3-d]pyrimidine...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of polymerase activity of recombinant HIV1 reverse polymerase assessed as reduction in extension of an 18 nucleotide DNA primer using temp... | Eur J Med Chem 141: 149-161 (2017) Article DOI: 10.1016/j.ejmech.2017.09.054 BindingDB Entry DOI: 10.7270/Q2N58PW6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50157832 (3-Hydroxy-4a,7a-dihydro-1H-thieno[2,3-d]pyrimidine...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of RNH activity of recombinant HIV1 reverse transcriptase RNase H assessed as reduction in internal cleavage of RNA strand using RNA/DNA d... | Eur J Med Chem 141: 149-161 (2017) Article DOI: 10.1016/j.ejmech.2017.09.054 BindingDB Entry DOI: 10.7270/Q2N58PW6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Deoxyribonuclease-1 (Homo sapiens (Human)) | BDBM50157832 (3-Hydroxy-4a,7a-dihydro-1H-thieno[2,3-d]pyrimidine...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
MRC Technology Curated by ChEMBL | Assay Description Inhibition of DNAse1 (unknown origin) | Bioorg Med Chem Lett 25: 4104-8 (2015) BindingDB Entry DOI: 10.7270/Q28S4RQ2 | |||||||||||
More data for this Ligand-Target Pair |