BDBM50157842 3-Hydroxy-5-methyl-4a,7a-dihydro-1H-thieno[2,3-d]pyrimidine-2,4-dione::CHEMBL183792

SMILES: Cc1csc2[nH]c(=O)n(O)c(=O)c12

InChI Key: InChIKey=VCPLNXWOFQOPTD-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50157842   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA excision repair protein ERCC-5 (Homo sapiens (Human))	BDBM50157842 (3-Hydroxy-5-methyl-4a,7a-dihydro-1H-thieno[2,3-d]p...) Show SMILES Cc1csc2[nH]c(=O)n(O)c(=O)c12 Show InChI InChI=1S/C7H6N2O3S/c1-3-2-13-5-4(3)6(10)9(12)7(11)8-5/h2,12H,1H3,(H,8,11)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.145	n/a	n/a	n/a	n/a	n/a	n/a
Athersys, Inc. Curated by ChEMBL					Assay Description Inhibitory concentration against the xeroderma pigmentosum G				Bioorg Med Chem Lett 15: 277-81 (2004) Article DOI: 10.1016/j.bmcl.2004.10.086 BindingDB Entry DOI: 10.7270/Q2HD7V46
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM50157842 (3-Hydroxy-5-methyl-4a,7a-dihydro-1H-thieno[2,3-d]p...) Show SMILES Cc1csc2[nH]c(=O)n(O)c(=O)c12 Show InChI InChI=1S/C7H6N2O3S/c1-3-2-13-5-4(3)6(10)9(12)7(11)8-5/h2,12H,1H3,(H,8,11)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0140	n/a	n/a	n/a	n/a	n/a	n/a
Athersys, Inc. Curated by ChEMBL					Assay Description Inhibitory concentration against the Flap endonuclease-1				Bioorg Med Chem Lett 15: 277-81 (2004) Article DOI: 10.1016/j.bmcl.2004.10.086 BindingDB Entry DOI: 10.7270/Q2HD7V46
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50157842 (3-Hydroxy-5-methyl-4a,7a-dihydro-1H-thieno[2,3-d]p...) Show SMILES Cc1csc2[nH]c(=O)n(O)c(=O)c12 Show InChI InChI=1S/C7H6N2O3S/c1-3-2-13-5-4(3)6(10)9(12)7(11)8-5/h2,12H,1H3,(H,8,11)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of RNH activity of recombinant HIV1 reverse transcriptase RNase H assessed as reduction in internal cleavage of RNA strand using RNA/DNA d...				Eur J Med Chem 141: 149-161 (2017) Article DOI: 10.1016/j.ejmech.2017.09.054 BindingDB Entry DOI: 10.7270/Q2N58PW6
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM50157842 (3-Hydroxy-5-methyl-4a,7a-dihydro-1H-thieno[2,3-d]p...) Show SMILES Cc1csc2[nH]c(=O)n(O)c(=O)c12 Show InChI InChI=1S/C7H6N2O3S/c1-3-2-13-5-4(3)6(10)9(12)7(11)8-5/h2,12H,1H3,(H,8,11)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of polymerase activity of recombinant HIV1 reverse polymerase assessed as reduction in extension of an 18 nucleotide DNA primer using temp...				Eur J Med Chem 141: 149-161 (2017) Article DOI: 10.1016/j.ejmech.2017.09.054 BindingDB Entry DOI: 10.7270/Q2N58PW6
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50157842 (3-Hydroxy-5-methyl-4a,7a-dihydro-1H-thieno[2,3-d]p...) Show SMILES Cc1csc2[nH]c(=O)n(O)c(=O)c12 Show InChI InChI=1S/C7H6N2O3S/c1-3-2-13-5-4(3)6(10)9(12)7(11)8-5/h2,12H,1H3,(H,8,11)	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Displacement of 125-I echistatin from Vitronectin receptor (alpha V beta 3)				Eur J Med Chem 141: 149-161 (2017) Article DOI: 10.1016/j.ejmech.2017.09.054 BindingDB Entry DOI: 10.7270/Q2N58PW6
					More data for this Ligand-Target Pair