BDBM50157846 3-Hydroxy-7-p-tolyl-1H-furo[3,2-d]pyrimidine-2,4-dione::CHEMBL182381

SMILES: Cc1ccc(cc1)-c1coc2c1[nH]c(=O)n(O)c2=O

InChI Key: InChIKey=FFGCIABZEPVWCP-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50157846   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA excision repair protein ERCC-5 (Homo sapiens (Human))	BDBM50157846 (3-Hydroxy-7-p-tolyl-1H-furo[3,2-d]pyrimidine-2,4-d...) Show SMILES Cc1ccc(cc1)-c1coc2c1[nH]c(=O)n(O)c2=O Show InChI InChI=1S/C13H10N2O4/c1-7-2-4-8(5-3-7)9-6-19-11-10(9)14-13(17)15(18)12(11)16/h2-6,18H,1H3,(H,14,17)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.128	n/a	n/a	n/a	n/a	n/a	n/a
Athersys, Inc. Curated by ChEMBL					Assay Description Inhibitory concentration against the xeroderma pigmentosum G				Bioorg Med Chem Lett 15: 277-81 (2004) Article DOI: 10.1016/j.bmcl.2004.10.086 BindingDB Entry DOI: 10.7270/Q2HD7V46
					More data for this Ligand-Target Pair
Deoxyribonuclease-1 (Homo sapiens (Human))	BDBM50157846 (3-Hydroxy-7-p-tolyl-1H-furo[3,2-d]pyrimidine-2,4-d...) Show SMILES Cc1ccc(cc1)-c1coc2c1[nH]c(=O)n(O)c2=O Show InChI InChI=1S/C13H10N2O4/c1-7-2-4-8(5-3-7)9-6-19-11-10(9)14-13(17)15(18)12(11)16/h2-6,18H,1H3,(H,14,17)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
MRC Technology Curated by ChEMBL					Assay Description Inhibition of DNAse1 (unknown origin)				Bioorg Med Chem Lett 25: 4104-8 (2015) BindingDB Entry DOI: 10.7270/Q28S4RQ2
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM50157846 (3-Hydroxy-7-p-tolyl-1H-furo[3,2-d]pyrimidine-2,4-d...) Show SMILES Cc1ccc(cc1)-c1coc2c1[nH]c(=O)n(O)c2=O Show InChI InChI=1S/C13H10N2O4/c1-7-2-4-8(5-3-7)9-6-19-11-10(9)14-13(17)15(18)12(11)16/h2-6,18H,1H3,(H,14,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
MRC Technology Curated by ChEMBL					Assay Description Inhibition of FEN1 (unknown origin)				Bioorg Med Chem Lett 25: 4104-8 (2015) BindingDB Entry DOI: 10.7270/Q28S4RQ2
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM50157846 (3-Hydroxy-7-p-tolyl-1H-furo[3,2-d]pyrimidine-2,4-d...) Show SMILES Cc1ccc(cc1)-c1coc2c1[nH]c(=O)n(O)c2=O Show InChI InChI=1S/C13H10N2O4/c1-7-2-4-8(5-3-7)9-6-19-11-10(9)14-13(17)15(18)12(11)16/h2-6,18H,1H3,(H,14,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0820	n/a	n/a	n/a	n/a	n/a	n/a
Athersys, Inc. Curated by ChEMBL					Assay Description Inhibitory concentration against the Flap endonuclease-1				Bioorg Med Chem Lett 15: 277-81 (2004) Article DOI: 10.1016/j.bmcl.2004.10.086 BindingDB Entry DOI: 10.7270/Q2HD7V46
					More data for this Ligand-Target Pair