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SMILES: Fc1cccc2CC3CCC(Cc12)C3NS(=O)(=O)c1ccc(Cl)s1

InChI Key: InChIKey=YTBSSZLYKCFJCT-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50157965   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2


(Homo sapiens (Human))		BDBM50157965
PNG
(5-Chloro-thiophene-2-sulfonic acid (4-fluoro-tricy...)
Show SMILES Fc1cccc2CC3CCC(Cc12)C3NS(=O)(=O)c1ccc(Cl)s1 |TLB:1:12:13:9.8,4:5:13:9.8,THB:14:13:12.11.5.6:9.8|
Show InChI InChI=1S/C17H17ClFNO2S2/c18-15-6-7-16(23-15)24(21,22)20-17-11-4-5-12(17)9-13-10(8-11)2-1-3-14(13)19/h1-3,6-7,11-12,17,20H,4-5,8-9H2
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Similars
Article
PubMed
n/an/a 34n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells

Bioorg Med Chem Lett 15: 373-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.062
BindingDB Entry DOI: 10.7270/Q2445KZQ
More data for this
Ligand-Target Pair