null

SMILES: Clc1ccc(s1)S(=O)(=O)NC1C2CCC1Cc1ccccc1C2

InChI Key: InChIKey=DIGSRNGZVYWJEK-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50157973   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Presenilin-1 (Homo sapiens (Human))	BDBM50157973 (5-chloro-thiophene-2-sulfonic acid tricyclo[8.2.1....) Show SMILES Clc1ccc(s1)S(=O)(=O)NC1C2CCC1Cc1ccccc1C2 |THB:17:16:10:12.13,9:10:22.15.16.21:12.13,20:21:10:12.13| Show InChI InChI=1S/C17H18ClNO2S2/c18-15-7-8-16(22-15)23(20,21)19-17-13-5-6-14(17)10-12-4-2-1-3-11(12)9-13/h1-4,7-8,13-14,17,19H,5-6,9-10H2	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human gamma secretase in human SHSY5Y cells				Bioorg Med Chem Lett 18: 375-9 (2008) Article DOI: 10.1016/j.bmcl.2007.10.057 BindingDB Entry DOI: 10.7270/Q29G5QKF
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50157973 (5-chloro-thiophene-2-sulfonic acid tricyclo[8.2.1....) Show SMILES Clc1ccc(s1)S(=O)(=O)NC1C2CCC1Cc1ccccc1C2 |THB:17:16:10:12.13,9:10:22.15.16.21:12.13,20:21:10:12.13| Show InChI InChI=1S/C17H18ClNO2S2/c18-15-7-8-16(22-15)23(20,21)19-17-13-5-6-14(17)10-12-4-2-1-3-11(12)9-13/h1-4,7-8,13-14,17,19H,5-6,9-10H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair