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SMILES: Clc1ccc(s1)S(=O)(=O)NC1C2CCC1Cc1cc(\C=C\Cn3ccnc3)ccc1C2

InChI Key: InChIKey=QGCMTZLAQQNVTP-OWOJBTEDSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50158009   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2


(Homo sapiens (Human))		BDBM50158009
PNG
(5-Chloro-thiophene-2-sulfonic acid [5-((E)-3-imida...)
Show SMILES Clc1ccc(s1)S(=O)(=O)NC1C2CCC1Cc1cc(\C=C\Cn3ccnc3)ccc1C2 |THB:9:10:16.29.15.30:12.13,17:16:10:12.13,28:29:10:12.13|
Show InChI InChI=1S/C23H24ClN3O2S2/c24-21-7-8-22(30-21)31(28,29)26-23-18-5-6-19(23)14-20-12-16(3-4-17(20)13-18)2-1-10-27-11-9-25-15-27/h1-4,7-9,11-12,15,18-19,23,26H,5-6,10,13-14H2/b2-1+
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Similars
Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells

Bioorg Med Chem Lett 15: 373-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.062
BindingDB Entry DOI: 10.7270/Q2445KZQ
More data for this
Ligand-Target Pair