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BDBM50158117 (5-{[(4-Chloro-benzyl)-(3,3,3-trifluoro-propyl)-amino]-methyl}-4-trifluoromethyl-thiazol-2-yl)-(2,4,6-trichloro-phenyl)-amine::CHEMBL181134

SMILES: FC(F)(F)CCN(Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)Cc1ccc(Cl)cc1

InChI Key: InChIKey=RMZZLRZAUNSNLY-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50158117   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50158117
PNG
((5-{[(4-Chloro-benzyl)-(3,3,3-trifluoro-propyl)-am...)
Show SMILES FC(F)(F)CCN(Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C21H15Cl4F6N3S/c22-12-3-1-11(2-4-12)9-34(6-5-20(26,27)28)10-16-18(21(29,30)31)33-19(35-16)32-17-14(24)7-13(23)8-15(17)25/h1-4,7-8H,5-6,9-10H2,(H,32,33)
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Article
PubMed
 3.20n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibtion of [125I]-Tyr-o-CRF binding to Corticotropin releasing factor receptor 1 expressed in IMR-32 human neuroblastoma cells

Bioorg Med Chem Lett 15: 431-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.055
BindingDB Entry DOI: 10.7270/Q2M61JR4
More data for this
Ligand-Target Pair