BDBM50158428 CHEMBL3787567

SMILES: Nc1ncnc2n(cc(-c3cccc(OCC45CCC(CC4)O5)c3)c12)[C@@H]1C[C@H](CO)C1

InChI Key: InChIKey=GGTFGDYZXJIORI-VGWTUOLASA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50158428   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50158428 (CHEMBL3787567) Show SMILES Nc1ncnc2n(cc(-c3cccc(OCC45CCC(CC4)O5)c3)c12)[C@@H]1C[C@H](CO)C1 |r,wD:25.29,27.32,(-1.03,2.79,;-1.03,1.56,;-2.38,.77,;-2.38,-.77,;-1.03,-1.56,;.3,-.77,;1.77,-1.24,;2.67,.02,;1.77,1.24,;2.24,2.71,;3.77,2.92,;4.35,4.36,;3.4,5.57,;1.87,5.35,;.91,6.57,;1.49,8.01,;.54,9.22,;-.78,8.63,;-1.88,9.69,;-1.51,11.18,;-.02,11.58,;1.07,10.52,;-.08,10.37,;1.29,3.92,;.3,.77,;2.25,-2.71,;3.55,-3.46,;2.75,-4.78,;3.11,-6.27,;4.29,-6.62,;1.43,-3.97,)| Show InChI InChI=1S/C24H28N4O3/c25-22-21-20(11-28(23(21)27-14-26-22)17-8-15(9-17)12-29)16-2-1-3-19(10-16)30-13-24-6-4-18(31-24)5-7-24/h1-3,10-11,14-15,17-18,29H,4-9,12-13H2,(H2,25,26,27)/t15-,17+,18?,24?	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	128	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of full length IGF-1 receptor (unknown origin) autophosphorylation transfected in HEK293 cells pretreated for 60 mins followed by IGF-1 st...				Bioorg Med Chem Lett 26: 2057-64 (2016) BindingDB Entry DOI: 10.7270/Q29K4D4J
					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50158428 (CHEMBL3787567) Show SMILES Nc1ncnc2n(cc(-c3cccc(OCC45CCC(CC4)O5)c3)c12)[C@@H]1C[C@H](CO)C1 |r,wD:25.29,27.32,(-1.03,2.79,;-1.03,1.56,;-2.38,.77,;-2.38,-.77,;-1.03,-1.56,;.3,-.77,;1.77,-1.24,;2.67,.02,;1.77,1.24,;2.24,2.71,;3.77,2.92,;4.35,4.36,;3.4,5.57,;1.87,5.35,;.91,6.57,;1.49,8.01,;.54,9.22,;-.78,8.63,;-1.88,9.69,;-1.51,11.18,;-.02,11.58,;1.07,10.52,;-.08,10.37,;1.29,3.92,;.3,.77,;2.25,-2.71,;3.55,-3.46,;2.75,-4.78,;3.11,-6.27,;4.29,-6.62,;1.43,-3.97,)| Show InChI InChI=1S/C24H28N4O3/c25-22-21-20(11-28(23(21)27-14-26-22)17-8-15(9-17)12-29)16-2-1-3-19(10-16)30-13-24-6-4-18(31-24)5-7-24/h1-3,10-11,14-15,17-18,29H,4-9,12-13H2,(H2,25,26,27)/t15-,17+,18?,24?	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of IGF-1 receptor (unknown origin) in presence of [gamma33P]ATP				Bioorg Med Chem Lett 26: 2057-64 (2016) BindingDB Entry DOI: 10.7270/Q29K4D4J
					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50158428 (CHEMBL3787567) Show SMILES Nc1ncnc2n(cc(-c3cccc(OCC45CCC(CC4)O5)c3)c12)[C@@H]1C[C@H](CO)C1 |r,wD:25.29,27.32,(-1.03,2.79,;-1.03,1.56,;-2.38,.77,;-2.38,-.77,;-1.03,-1.56,;.3,-.77,;1.77,-1.24,;2.67,.02,;1.77,1.24,;2.24,2.71,;3.77,2.92,;4.35,4.36,;3.4,5.57,;1.87,5.35,;.91,6.57,;1.49,8.01,;.54,9.22,;-.78,8.63,;-1.88,9.69,;-1.51,11.18,;-.02,11.58,;1.07,10.52,;-.08,10.37,;1.29,3.92,;.3,.77,;2.25,-2.71,;3.55,-3.46,;2.75,-4.78,;3.11,-6.27,;4.29,-6.62,;1.43,-3.97,)| Show InChI InChI=1S/C24H28N4O3/c25-22-21-20(11-28(23(21)27-14-26-22)17-8-15(9-17)12-29)16-2-1-3-19(10-16)30-13-24-6-4-18(31-24)5-7-24/h1-3,10-11,14-15,17-18,29H,4-9,12-13H2,(H2,25,26,27)/t15-,17+,18?,24?	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of full length IGF-1 receptor (unknown origin) transfected in Ba/F3 cells assessed as cell proliferation				Bioorg Med Chem Lett 26: 2057-64 (2016) BindingDB Entry DOI: 10.7270/Q29K4D4J
					More data for this Ligand-Target Pair