BDBM50158489 CHEMBL3786558

SMILES: CC12CCC(COc3cccc(c3)-c3cn([C@@H]4C[C@H](CO)C4)c4ncnc(N)c34)(CC1)O2

InChI Key: InChIKey=RCXOHBIYCKGQFU-XALROXTMSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50158489   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50158489 (CHEMBL3786558) Show SMILES CC12CCC(COc3cccc(c3)-c3cn([C@@H]4C[C@H](CO)C4)c4ncnc(N)c34)(CC1)O2 |r,wD:16.16,18.19,(.1,11.39,;.34,10.18,;-.59,8.36,;-.43,7.48,;.54,9.2,;1.49,7.98,;.91,6.55,;1.86,5.34,;3.38,5.55,;4.33,4.34,;3.76,2.91,;2.23,2.7,;1.29,3.91,;1.76,1.24,;2.66,.02,;1.76,-1.24,;2.24,-2.7,;3.54,-3.45,;2.74,-4.76,;3.1,-6.25,;4.28,-6.6,;1.42,-3.96,;.3,-.77,;-1.03,-1.55,;-2.38,-.77,;-2.38,.77,;-1.03,1.55,;-1.03,2.79,;.3,.77,;2.22,9.74,;2.09,10.51,;-.91,11.09,)| Show InChI InChI=1S/C25H30N4O3/c1-24-5-7-25(32-24,8-6-24)14-31-19-4-2-3-17(11-19)20-12-29(18-9-16(10-18)13-30)23-21(20)22(26)27-15-28-23/h2-4,11-12,15-16,18,30H,5-10,13-14H2,1H3,(H2,26,27,28)/t16-,18+,24?,25?	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	183	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of full length IGF-1 receptor (unknown origin) autophosphorylation transfected in HEK293 cells pretreated for 60 mins followed by IGF-1 st...				Bioorg Med Chem Lett 26: 2057-64 (2016) BindingDB Entry DOI: 10.7270/Q29K4D4J
					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50158489 (CHEMBL3786558) Show SMILES CC12CCC(COc3cccc(c3)-c3cn([C@@H]4C[C@H](CO)C4)c4ncnc(N)c34)(CC1)O2 |r,wD:16.16,18.19,(.1,11.39,;.34,10.18,;-.59,8.36,;-.43,7.48,;.54,9.2,;1.49,7.98,;.91,6.55,;1.86,5.34,;3.38,5.55,;4.33,4.34,;3.76,2.91,;2.23,2.7,;1.29,3.91,;1.76,1.24,;2.66,.02,;1.76,-1.24,;2.24,-2.7,;3.54,-3.45,;2.74,-4.76,;3.1,-6.25,;4.28,-6.6,;1.42,-3.96,;.3,-.77,;-1.03,-1.55,;-2.38,-.77,;-2.38,.77,;-1.03,1.55,;-1.03,2.79,;.3,.77,;2.22,9.74,;2.09,10.51,;-.91,11.09,)| Show InChI InChI=1S/C25H30N4O3/c1-24-5-7-25(32-24,8-6-24)14-31-19-4-2-3-17(11-19)20-12-29(18-9-16(10-18)13-30)23-21(20)22(26)27-15-28-23/h2-4,11-12,15-16,18,30H,5-10,13-14H2,1H3,(H2,26,27,28)/t16-,18+,24?,25?	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of full length IGF-1 receptor (unknown origin) transfected in Ba/F3 cells assessed as cell proliferation				Bioorg Med Chem Lett 26: 2057-64 (2016) BindingDB Entry DOI: 10.7270/Q29K4D4J
					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50158489 (CHEMBL3786558) Show SMILES CC12CCC(COc3cccc(c3)-c3cn([C@@H]4C[C@H](CO)C4)c4ncnc(N)c34)(CC1)O2 |r,wD:16.16,18.19,(.1,11.39,;.34,10.18,;-.59,8.36,;-.43,7.48,;.54,9.2,;1.49,7.98,;.91,6.55,;1.86,5.34,;3.38,5.55,;4.33,4.34,;3.76,2.91,;2.23,2.7,;1.29,3.91,;1.76,1.24,;2.66,.02,;1.76,-1.24,;2.24,-2.7,;3.54,-3.45,;2.74,-4.76,;3.1,-6.25,;4.28,-6.6,;1.42,-3.96,;.3,-.77,;-1.03,-1.55,;-2.38,-.77,;-2.38,.77,;-1.03,1.55,;-1.03,2.79,;.3,.77,;2.22,9.74,;2.09,10.51,;-.91,11.09,)| Show InChI InChI=1S/C25H30N4O3/c1-24-5-7-25(32-24,8-6-24)14-31-19-4-2-3-17(11-19)20-12-29(18-9-16(10-18)13-30)23-21(20)22(26)27-15-28-23/h2-4,11-12,15-16,18,30H,5-10,13-14H2,1H3,(H2,26,27,28)/t16-,18+,24?,25?	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of IGF-1 receptor (unknown origin) in presence of [gamma33P]ATP				Bioorg Med Chem Lett 26: 2057-64 (2016) BindingDB Entry DOI: 10.7270/Q29K4D4J
					More data for this Ligand-Target Pair