BindingDB PrimarySearch

BDBM50158983 CHEMBL439883::E G P P I S I D L S L E L L R K M I E I E K Q E K E K Q Q A A N N R L L L D T I-NH2(Sauvagine)::SAUVAGINE

SMILES: CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O

InChI Key: InChIKey=KFUIXDNQSMKKJQ-ZLFMSJRASA-N

Data: 2 KI 3 IC50 2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50158983
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50158983 (CHEMBL439883 \| E G P P I S I D L S L E L L R K M I...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Displacement of [125I]-Tyr0-sauvagine from CRF1 receptor (unknown origin)				Bioorg Med Chem Lett 25: 5111-4 (2015) BindingDB Entry DOI: 10.7270/Q2XW4MM0
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50158983 (CHEMBL439883 \| E G P P I S I D L S L E L L R K M I...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Displacement of [125I]-Tyr0-sauvagine from human CRF1 receptor expressed in HEK293T cells after 2 hrs by scintillation counting				Bioorg Med Chem Lett 25: 5111-4 (2015) BindingDB Entry DOI: 10.7270/Q2XW4MM0
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor 2 (Homo sapiens (Human))	BDBM50158983 (CHEMBL439883 \| E G P P I S I D L S L E L L R K M I...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Salk Institute Curated by ChEMBL					Assay Description Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu...				J Med Chem 45: 4737-47 (2002) BindingDB Entry DOI: 10.7270/Q2WQ04JR
Salk Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Corticotropin releasing hormone receptor 2 (Sus scrofa)	BDBM50158983 (CHEMBL439883 \| E G P P I S I D L S L E L L R K M I...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.580	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Displacement of [125I]sauvagine from CRF2 receptor in pig choroid plexus by rapid filtration technique				J Med Chem 52: 4161-72 (2009) Article DOI: 10.1021/jm900302q BindingDB Entry DOI: 10.7270/Q2WW7JM0
Bristol-Myers Squibb Company Curated by ChEMBL					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50158983 (CHEMBL439883 \| E G P P I S I D L S L E L L R K M I...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Salk Institute Curated by ChEMBL					Assay Description Inhibition of recombinant corticotropin releasing factor receptor 1 assayed using nonselective [125I]-labeled agonist [Tyr0,Glu1,Nle17]-sauvagine				J Med Chem 45: 4737-47 (2002) BindingDB Entry DOI: 10.7270/Q2WQ04JR
Salk Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor 1 (MOUSE)	BDBM50158983 (CHEMBL439883 \| E G P P I S I D L S L E L L R K M I...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
Procter & Gamble Pharmaceuticals Curated by ChEMBL					Assay Description In vitro effective concentration for mouse corticotropin releasing factor 1 receptor				J Med Chem 48: 262-5 (2005) Article DOI: 10.1021/jm049490m BindingDB Entry DOI: 10.7270/Q2WH2PG5
Procter & Gamble Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor 2 (Mus musculus)	BDBM50158983 (CHEMBL439883 \| E G P P I S I D L S L E L L R K M I...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
Procter & Gamble Pharmaceuticals Curated by ChEMBL					Assay Description In vitro effective concentration for mouse corticotropin releasing factor 2 receptor				J Med Chem 48: 262-5 (2005) Article DOI: 10.1021/jm049490m BindingDB Entry DOI: 10.7270/Q2WH2PG5
Procter & Gamble Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair