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SMILES: COc1ccc(cc1)-c1nnc(o1)C(=O)N1CC(C1)Oc1ccc(CN2CCN(C)CC2)c(F)c1

InChI Key: InChIKey=JZBRROOMXUTJLB-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50159329   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanin-concentrating hormone receptor 1 (Homo sapiens (Human))	BDBM50159329 (CHEMBL3787461) Show SMILES COc1ccc(cc1)-c1nnc(o1)C(=O)N1CC(C1)Oc1ccc(CN2CCN(C)CC2)c(F)c1 Show InChI InChI=1S/C25H28FN5O4/c1-29-9-11-30(12-10-29)14-18-5-8-20(13-22(18)26)34-21-15-31(16-21)25(32)24-28-27-23(35-24)17-3-6-19(33-2)7-4-17/h3-8,13,21H,9-12,14-16H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Displacement of [125I]Tyr13-MCH from human MCHR1 expressed in CHO cell membranes after 60 mins by microbeta scintillation counting analysis				J Med Chem 59: 2497-511 (2016) BindingDB Entry DOI: 10.7270/Q23R0VSS
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor 1 (Homo sapiens (Human))	BDBM50159329 (CHEMBL3787461) Show SMILES COc1ccc(cc1)-c1nnc(o1)C(=O)N1CC(C1)Oc1ccc(CN2CCN(C)CC2)c(F)c1 Show InChI InChI=1S/C25H28FN5O4/c1-29-9-11-30(12-10-29)14-18-5-8-20(13-22(18)26)34-21-15-31(16-21)25(32)24-28-27-23(35-24)17-3-6-19(33-2)7-4-17/h3-8,13,21H,9-12,14-16H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human MCHR1 expressed in CHO cell membranes preincubated for 5 mins followed by addition of MCH peptide measured after 45 mins...				J Med Chem 59: 2497-511 (2016) BindingDB Entry DOI: 10.7270/Q23R0VSS
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50159329 (CHEMBL3787461) Show SMILES COc1ccc(cc1)-c1nnc(o1)C(=O)N1CC(C1)Oc1ccc(CN2CCN(C)CC2)c(F)c1 Show InChI InChI=1S/C25H28FN5O4/c1-29-9-11-30(12-10-29)14-18-5-8-20(13-22(18)26)34-21-15-31(16-21)25(32)24-28-27-23(35-24)17-3-6-19(33-2)7-4-17/h3-8,13,21H,9-12,14-16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>3.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human ERG by IonWork assay				J Med Chem 59: 2497-511 (2016) BindingDB Entry DOI: 10.7270/Q23R0VSS
					More data for this Ligand-Target Pair