BDBM50159549 CHEMBL3786247

SMILES: COc1c(NC(=O)C(=O)c2ccc(OCCN3CCOCC3)c3ccccc23)cc(cc1NS(=O)(=O)CCCN(CC(O)=O)CC(O)=O)C(C)(C)C

InChI Key: InChIKey=GDNKEGLHGCLIOU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50159549   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Scavenger receptor class B member 1 (Homo sapiens (Human))	BDBM50159549 (CHEMBL3786247) Show SMILES COc1c(NC(=O)C(=O)c2ccc(OCCN3CCOCC3)c3ccccc23)cc(cc1NS(=O)(=O)CCCN(CC(O)=O)CC(O)=O)C(C)(C)C Show InChI InChI=1S/C36H46N4O11S/c1-36(2,3)24-20-28(34(49-4)29(21-24)38-52(47,48)19-7-12-40(22-31(41)42)23-32(43)44)37-35(46)33(45)27-10-11-30(26-9-6-5-8-25(26)27)51-18-15-39-13-16-50-17-14-39/h5-6,8-11,20-21,38H,7,12-19,22-23H2,1-4H3,(H,37,46)(H,41,42)(H,43,44)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.01E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of human SR-B1 transiently expressed in human U2OS cells assessed as Dil-HDL uptake preincubated for 2 hrs followed by Dil-HDL addition me...				Bioorg Med Chem Lett 26: 1901-4 (2016) BindingDB Entry DOI: 10.7270/Q22R3TJ2
					More data for this Ligand-Target Pair