BindingDB PrimarySearch

BDBM50160165 CHEMBL88272::RS-17053::[2-(2-Cyclopropylmethoxy-phenoxy)-ethyl]-[2-(1H-indol-3-yl)-1,1-dimethyl-ethyl]-amine::[2-(5-Chloro-1H-indol-3-yl)-1,1-dimethyl-ethyl]-[2-(2-cyclopropylmethoxy-phenoxy)-ethyl]-amine

SMILES: CC(C)(Cc1c[nH]c2ccc(Cl)cc12)NCCOc1ccccc1OCC1CC1

InChI Key: InChIKey=XLZHXAXXJVKTFM-UHFFFAOYSA-N

Data: 5 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50160165
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50160165 (CHEMBL88272 \| RS-17053 \| [2-(2-Cyclopropylmethoxy-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Dublin Curated by PDSP K_i Database									J Med Chem 49: 501-10 (2006) Article DOI: 10.1021/jm0503751 BindingDB Entry DOI: 10.7270/Q29G5KC3
University of Dublin Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50160165 (CHEMBL88272 \| RS-17053 \| [2-(2-Cyclopropylmethoxy-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Binding constant measured against Alpha-1A adrenergic receptor in human prostate; +++:highly active				Bioorg Med Chem Lett 15: 657-64 (2005) Article DOI: 10.1016/j.bmcl.2004.11.032 BindingDB Entry DOI: 10.7270/Q2SN08GW
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Cerebral cortex alpha adrenergic receptor (CALF)	BDBM50160165 (CHEMBL88272 \| RS-17053 \| [2-(2-Cyclopropylmethoxy-...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	0.794	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Roche Bioscience Curated by ChEMBL					Assay Description In vitro for the displacement of [3H]prazosin binding to bovine Alpha-1A adrenergic receptor				J Med Chem 40: 2674-87 (1997) Checked by Author Article DOI: 10.1021/jm970166j BindingDB Entry DOI: 10.7270/Q2R78GD2
Roche Bioscience Curated by ChEMBL					More data for this Ligand-Target Pair
ADRA1B (Mus musculus)	BDBM50160165 (CHEMBL88272 \| RS-17053 \| [2-(2-Cyclopropylmethoxy-...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Dublin Curated by PDSP K_i Database									J Med Chem 49: 501-10 (2006) Article DOI: 10.1021/jm0503751 BindingDB Entry DOI: 10.7270/Q29G5KC3
University of Dublin Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50160165 (CHEMBL88272 \| RS-17053 \| [2-(2-Cyclopropylmethoxy-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Dublin Curated by PDSP K_i Database									J Med Chem 49: 501-10 (2006) Article DOI: 10.1021/jm0503751 BindingDB Entry DOI: 10.7270/Q29G5KC3
University of Dublin Curated by PDSP K_i Database					More data for this Ligand-Target Pair