BDBM50160730 3-{(S)-Methyl-[5-(4-trifluoromethyl-phenyl)-thiophene-2-carbonyl]-amino}-pyrrolidine-1-carboxylic acid [(R)-1-(4,4-dimethyl-cyclohexyl)-pyrrolidin-3-yl]-methyl-amide
SMILES: CN([C@@H]1CCN(C1)C1CCC(C)(C)CC1)C(=O)N1CCC(C1)N(C)C(=O)c1ccc(s1)-c1ccc(cc1)C(F)(F)F
InChI Key: InChIKey=HCNXPYMDAMAEAE-WUBHUQEYSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Melanin-concentrating hormone receptor (Homo sapiens (Human)) | BDBM50160730 (3-{(S)-Methyl-[5-(4-trifluoromethyl-phenyl)-thioph...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc. Curated by ChEMBL | Assay Description Displacement of [125I]MCH from human Melanin-concentrating hormone 1 (MCH1) receptor modified for optimal expression in HEK293 cells | Bioorg Med Chem Lett 15: 999-1004 (2005) Article DOI: 10.1016/j.bmcl.2004.12.036 BindingDB Entry DOI: 10.7270/Q21R6R9X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanin-concentrating hormone receptor (Homo sapiens (Human)) | BDBM50160730 (3-{(S)-Methyl-[5-(4-trifluoromethyl-phenyl)-thioph...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 338 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc. Curated by ChEMBL | Assay Description Displacement of [125I]MCH from human Melanin-concentrating hormone 1 (MCH1) receptor modified for optimal expression in HEK293 cells | Bioorg Med Chem Lett 15: 999-1004 (2005) Article DOI: 10.1016/j.bmcl.2004.12.036 BindingDB Entry DOI: 10.7270/Q21R6R9X | |||||||||||
More data for this Ligand-Target Pair |