BDBM50161084 1,2,3,4,5,6-Hexahydro-1,5-methano-pyrido[1,2-a][1,5]diazocine-8-thione::CHEMBL293649

SMILES: S=c1cccc2C3CNCC(C3)Cn12

InChI Key: InChIKey=SXRPRXJTRLBYNK-UHFFFAOYSA-N

Data: 1 KI  3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50161084   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit (Rattus norvegicus (Rat))	BDBM50161084 (1,2,3,4,5,6-Hexahydro-1,5-methano-pyrido[1,2-a][1,...) Show SMILES S=c1cccc2C3CNCC(C3)Cn12 |THB:4:5:11:8.7.9| Show InChI InChI=1S/C11H14N2S/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	1.00E+14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institut f£r Pharmazeutische Chemie der Philipps-Universit£t Marburg Curated by ChEMBL					Assay Description In vitro binding affinity towards (alpha-4)2(beta-2)3 neuronal nicotinic acetylcholine receptor in P2 membrane fractions of rat forebrain				J Med Chem 46: 2031-48 (2003) Article DOI: 10.1021/jm020859m BindingDB Entry DOI: 10.7270/Q2N87DHM
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2 (Homo sapiens (Human))	BDBM50161084 (1,2,3,4,5,6-Hexahydro-1,5-methano-pyrido[1,2-a][1,...) Show SMILES S=c1cccc2C3CNCC(C3)Cn12 |THB:4:5:11:8.7.9| Show InChI InChI=1S/C11H14N2S/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.20	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL					Assay Description Change in membrane potential in K-177 cells expressing acetylcholine central neuronal receptor alpha4-beta2 subunits				Bioorg Med Chem Lett 15: 1221-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.073 BindingDB Entry DOI: 10.7270/Q2DJ5GVR
					More data for this Ligand-Target Pair
Acetylcholine receptor protein alpha chain/beta chain/delta chain /gamma chain (Homo sapiens (Human))	BDBM50161084 (1,2,3,4,5,6-Hexahydro-1,5-methano-pyrido[1,2-a][1,...) Show SMILES S=c1cccc2C3CNCC(C3)Cn12 |THB:4:5:11:8.7.9| Show InChI InChI=1S/C11H14N2S/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>100	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL					Assay Description Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptors				Bioorg Med Chem Lett 15: 1221-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.073 BindingDB Entry DOI: 10.7270/Q2DJ5GVR
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-3/Beta-4 (Rattus norvegicus (Rat))	BDBM50161084 (1,2,3,4,5,6-Hexahydro-1,5-methano-pyrido[1,2-a][1,...) Show SMILES S=c1cccc2C3CNCC(C3)Cn12 |THB:4:5:11:8.7.9| Show InChI InChI=1S/C11H14N2S/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>100	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL					Assay Description Effective concentration in KXalpha-3-beta-4R2 cells expressing rat nicotinic acetylcholine receptor alpha3-beta4 subunits				Bioorg Med Chem Lett 15: 1221-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.073 BindingDB Entry DOI: 10.7270/Q2DJ5GVR
					More data for this Ligand-Target Pair