null
SMILES: C[C@H]1CNCCc2ccc(Cl)cc12
InChI Key: InChIKey=XTTZERNUQAFMOF-QMMMGPOBSA-N
PDB links: 3 PDB IDs match this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50161646 ((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation | J Med Chem 51: 305-13 (2008) Article DOI: 10.1021/jm0709034 BindingDB Entry DOI: 10.7270/Q26Q211B | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM50161646 ((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 79 | n/a | n/a | n/a | n/a |
University of Illinois at Chicago Curated by ChEMBL | Assay Description Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fl... | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111626 BindingDB Entry DOI: 10.7270/Q24J0JG8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50161646 ((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a |
University of Illinois at Chicago Curated by ChEMBL | Assay Description Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measur... | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111626 BindingDB Entry DOI: 10.7270/Q24J0JG8 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM50161646 ((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 80 | n/a | n/a | n/a | n/a |
University of Illinois at Chicago Curated by ChEMBL | Assay Description Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fl... | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111626 BindingDB Entry DOI: 10.7270/Q24J0JG8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50161646 ((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 33 | n/a | n/a | n/a | n/a |
University of Illinois at Chicago Curated by ChEMBL | Assay Description Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fl... | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111626 BindingDB Entry DOI: 10.7270/Q24J0JG8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50161646 ((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 32 | n/a | n/a | n/a | n/a |
University of Illinois at Chicago Curated by ChEMBL | Assay Description Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fl... | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111626 BindingDB Entry DOI: 10.7270/Q24J0JG8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50161646 ((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a |
University of Illinois at Chicago Curated by ChEMBL | Assay Description Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measur... | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111626 BindingDB Entry DOI: 10.7270/Q24J0JG8 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50161646 ((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.92E+3 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Partial agonist activity at 5HT2A receptor (unknown origin) | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126929 BindingDB Entry DOI: 10.7270/Q28W3HT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50161646 ((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 7.60 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at recombinant human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate measured after 2 hrs in... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126929 BindingDB Entry DOI: 10.7270/Q28W3HT5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50161646 ((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 dire... | Citation and Details BindingDB Entry DOI: 10.7270/Q28P6455 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50161646 ((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 dire... | Citation and Details BindingDB Entry DOI: 10.7270/Q28P6455 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM50161646 ((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 437 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 dire... | Citation and Details BindingDB Entry DOI: 10.7270/Q28P6455 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM50161646 ((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 433 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 dire... | Citation and Details BindingDB Entry DOI: 10.7270/Q28P6455 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50161646 ((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 245 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 dire... | Citation and Details BindingDB Entry DOI: 10.7270/Q28P6455 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50161646 ((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 248 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 dire... | Citation and Details BindingDB Entry DOI: 10.7270/Q28P6455 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50161646 ((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 ... | Citation and Details BindingDB Entry DOI: 10.7270/Q28P6455 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50161646 ((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 ... | Citation and Details BindingDB Entry DOI: 10.7270/Q28P6455 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50161646 ((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | n/a | n/a | 59 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 h... | Citation and Details BindingDB Entry DOI: 10.7270/Q28P6455 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50161646 ((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | n/a | n/a | 59 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 h... | Citation and Details BindingDB Entry DOI: 10.7270/Q28P6455 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |
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