BDBM50161753 CHEMBL554984::N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide; compound with hydrochloride
SMILES: Clc1ccc(cc1)C(=O)N[C@H]1CN2CCC1CC2
InChI Key: InChIKey=WECKJONDRAUFDD-ZDUSSCGKSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neuronal acetylcholine receptor (Rattus norvegicus (Rat)) | BDBM50161753 (CHEMBL554984 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of methyllycaconitine (MLA) binding to Nicotinic acetylcholine receptor alpha-7 in rat brain homogenates | J Med Chem 48: 905-8 (2005) Article DOI: 10.1021/jm049363q BindingDB Entry DOI: 10.7270/Q2ZC83MF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Rattus norvegicus-RAT) | BDBM50161753 (CHEMBL554984 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.66E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor from rat brain homogenates | J Med Chem 48: 905-8 (2005) Article DOI: 10.1021/jm049363q BindingDB Entry DOI: 10.7270/Q2ZC83MF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Rattus norvegicus-RAT) | BDBM50161753 (CHEMBL554984 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Functional antagonism of rat 5-hydroxytryptamine 3 receptor in cell-based FLIPR assay | J Med Chem 48: 905-8 (2005) Article DOI: 10.1021/jm049363q BindingDB Entry DOI: 10.7270/Q2ZC83MF | |||||||||||
More data for this Ligand-Target Pair |