BDBM50162142 1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(2-fluoro-phenyl)-urea::CHEMBL179227
SMILES: COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4F)cc3)c2cc1OC
InChI Key: InChIKey=SFUSDJRVEVLCSW-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Platelet-derived growth factor receptor alpha (Homo sapiens (Human)) | BDBM50162142 (1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(2...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd. Curated by ChEMBL | Assay Description Inhibition of platelet-derived growth factor receptor alpha | J Med Chem 48: 1359-66 (2005) Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50162142 (1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(2...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd. Curated by ChEMBL | Assay Description Inhibition of vascular endothelial growth factor receptor 2 | J Med Chem 48: 1359-66 (2005) Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 | |||||||||||
More data for this Ligand-Target Pair |