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BDBM50162568 6,7-Dichloro-2-cyclopentyl-5-[4-(2H-tetrazol-5-yl)-benzyloxy]-indan-1-one::CHEMBL179939

SMILES: Clc1c2C(=O)C(Cc2cc(OCc2ccc(cc2)-c2nnn[nH]2)c1Cl)C1CCCC1

InChI Key: InChIKey=XUGRGRMGJJYIJM-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50162568   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50162568
PNG
(6,7-Dichloro-2-cyclopentyl-5-[4-(2H-tetrazol-5-yl)...)
Show SMILES Clc1c2C(=O)C(Cc2cc(OCc2ccc(cc2)-c2nnn[nH]2)c1Cl)C1CCCC1
Show InChI InChI=1S/C22H20Cl2N4O2/c23-19-17(30-11-12-5-7-14(8-6-12)22-25-27-28-26-22)10-15-9-16(13-3-1-2-4-13)21(29)18(15)20(19)24/h5-8,10,13,16H,1-4,9,11H2,(H,25,26,27,28)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/a 122n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity against metabotropic glutamate receptor 2


Bioorg Med Chem Lett 15: 1565-71 (2005)


Article DOI: 10.1016/j.bmcl.2005.01.077
BindingDB Entry DOI: 10.7270/Q2XW4JBK
More data for this
Ligand-Target Pair