Found 12 hits for monomerid = 50162816 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Type IV secretion-like conjugative transfer relaxase protein TraI
(Escherichia coli (strain SMS-3-5 / SECEC)) | BDBM50162816
(CHEMBL180570 | Medronic acid | Methylene diphsphon...)Show InChI InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7) | PDB
UniProtKB/TrEMBL
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| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina
Curated by ChEMBL
| Assay Description Inhibition of Escherichia coli F plasmid TraI relaxase Y16F mutant assessed as oriT ssDNA cleavage by competitive inhibition assay |
Proc Natl Acad Sci U S A 104: 12282-7 (2007)
Article DOI: 10.1073/pnas.0702760104 BindingDB Entry DOI: 10.7270/Q2PK0JXD |
More data for this Ligand-Target Pair | |
Fe(3+)-Zn(2+) purple acid phosphatase
(Phaseolus vulgaris) | BDBM50162816
(CHEMBL180570 | Medronic acid | Methylene diphsphon...)Show InChI InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7) | PDB MMDB
UniProtKB/SwissProt
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| 1.40E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Inhibition of red kidney beans purple acid phosphatase |
Eur J Med Chem 76: 132-44 (2014)
Article DOI: 10.1016/j.ejmech.2014.02.008 BindingDB Entry DOI: 10.7270/Q2T43VM0 |
More data for this Ligand-Target Pair | |
Carbonic Anhydrase VA
(Homo sapiens (Human)) | BDBM50162816
(CHEMBL180570 | Medronic acid | Methylene diphsphon...)Show InChI InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7) | Reactome pathway KEGG
UniProtKB/SwissProt
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| 7.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université Montpellier II
Curated by ChEMBL
| Assay Description Binding affinity towards recombinant human mitochondrial carbonic anhydrase V |
Bioorg Med Chem Lett 15: 1683-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.01.049 BindingDB Entry DOI: 10.7270/Q2NC60PJ |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 9
(Homo sapiens (Human)) | BDBM50162816
(CHEMBL180570 | Medronic acid | Methylene diphsphon...)Show InChI InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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| 8.60E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université Montpellier II
Curated by ChEMBL
| Assay Description Binding affinity owards recombinant human transmembrane carbonic anhydrase IX |
Bioorg Med Chem Lett 15: 1683-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.01.049 BindingDB Entry DOI: 10.7270/Q2NC60PJ |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM50162816
(CHEMBL180570 | Medronic acid | Methylene diphsphon...)Show InChI InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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| 1.25E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université Montpellier II
Curated by ChEMBL
| Assay Description Binding affinity towards human cytosolic carbonic anhydrase II |
Bioorg Med Chem Lett 15: 1683-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.01.049 BindingDB Entry DOI: 10.7270/Q2NC60PJ |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 4
(Homo sapiens (Human)) | BDBM50162816
(CHEMBL180570 | Medronic acid | Methylene diphsphon...)Show InChI InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| 5.34E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université Montpellier II
Curated by ChEMBL
| Assay Description Binding affinity towards human membrane associated carbonic anhydrase IV |
Bioorg Med Chem Lett 15: 1683-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.01.049 BindingDB Entry DOI: 10.7270/Q2NC60PJ |
More data for this Ligand-Target Pair | |
Ornithine carbamoyltransferase
(Homo sapiens (Human)) | BDBM50162816
(CHEMBL180570 | Medronic acid | Methylene diphsphon...)Show InChI InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| 9.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
Universit£tstrasse 16
Curated by ChEMBL
| Assay Description Binding affinity against ornithine transcarbamoylase (OTC) produced by Streptococcus faecalis The buffer taken for this study is 50 mM Tris.HCl, 0.5 ... |
J Med Chem 42: 2633-40 (1999)
Article DOI: 10.1021/jm991008q BindingDB Entry DOI: 10.7270/Q2NV9JX8 |
More data for this Ligand-Target Pair | |
Ornithine carbamoyltransferase
(Homo sapiens (Human)) | BDBM50162816
(CHEMBL180570 | Medronic acid | Methylene diphsphon...)Show InChI InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| >2.00E+7 | n/a | n/a | n/a | n/a | n/a | n/a | 7.0 | n/a |
Universit£tstrasse 16
Curated by ChEMBL
| Assay Description Binding affinity against ornithine transcarbamoylase (OTC) produced by Streptococcus faecalis The buffer taken for this study is 50 mM Tris.HCl, 0.5 ... |
J Med Chem 42: 2633-40 (1999)
Article DOI: 10.1021/jm991008q BindingDB Entry DOI: 10.7270/Q2NV9JX8 |
More data for this Ligand-Target Pair | |
Ornithine carbamoyltransferase
(Homo sapiens (Human)) | BDBM50162816
(CHEMBL180570 | Medronic acid | Methylene diphsphon...)Show InChI InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| >2.00E+7 | n/a | n/a | n/a | n/a | n/a | n/a | 6.0 | n/a |
Universit£tstrasse 16
Curated by ChEMBL
| Assay Description Binding affinity against ornithine transcarbamoylase (OTC) produced by Streptococcus faecalis The buffer taken for this study is 50 mM maleate, 0.5 m... |
J Med Chem 42: 2633-40 (1999)
Article DOI: 10.1021/jm991008q BindingDB Entry DOI: 10.7270/Q2NV9JX8 |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 9
(Homo sapiens (Human)) | BDBM50162816
(CHEMBL180570 | Medronic acid | Methylene diphsphon...)Show InChI InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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| n/a | n/a | 8.60E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi
Curated by ChEMBL
| Assay Description Inhibition of human recombinant carbonic anhydrase 9 pretreated for 15 mins by stopped flow CO2 hydrase assay |
Bioorg Med Chem Lett 24: 2617-20 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.077 BindingDB Entry DOI: 10.7270/Q2GB25KV |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM50162816
(CHEMBL180570 | Medronic acid | Methylene diphsphon...)Show InChI InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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| n/a | n/a | 1.25E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi
Curated by ChEMBL
| Assay Description Inhibition of human recombinant carbonic anhydrase 2 pretreated for 15 mins by stopped flow CO2 hydrase assay |
Bioorg Med Chem Lett 24: 2617-20 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.077 BindingDB Entry DOI: 10.7270/Q2GB25KV |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50162816
(CHEMBL180570 | Medronic acid | Methylene diphsphon...)Show InChI InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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| n/a | n/a | 4.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP-2 pretreated for 30 mins measured 2 to 4 hrs after Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate addition by fluo... |
Bioorg Med Chem Lett 24: 2617-20 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.077 BindingDB Entry DOI: 10.7270/Q2GB25KV |
More data for this Ligand-Target Pair | |