BDBM50163651 1-{(1R,2S)-2-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-cyclohexyl}-3-(2-methoxy-phenyl)-urea::CHEMBL175634

SMILES: COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1

InChI Key: InChIKey=UKGNFGQNYLRGJL-WPFOTENUSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50163651   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-C chemokine receptor type 3 (Homo sapiens (Human))	BDBM50163651 (1-{(1R,2S)-2-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-...) Show SMILES COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 Show InChI InChI=1S/C27H36FN3O2/c1-33-26-11-5-4-10-25(26)30-27(32)29-24-9-3-2-8-22(24)19-31-16-6-7-21(18-31)17-20-12-14-23(28)15-13-20/h4-5,10-15,21-22,24H,2-3,6-9,16-19H2,1H3,(H2,29,30,32)/t21-,22-,24+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	115	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of eotaxin-induced chemotaxis of human eosinophils				J Med Chem 48: 2194-211 (2005) Article DOI: 10.1021/jm049530m BindingDB Entry DOI: 10.7270/Q2XP74F1
					More data for this Ligand-Target Pair
C-C chemokine receptor type 3 (Homo sapiens (Human))	BDBM50163651 (1-{(1R,2S)-2-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-...) Show SMILES COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 Show InChI InChI=1S/C27H36FN3O2/c1-33-26-11-5-4-10-25(26)30-27(32)29-24-9-3-2-8-22(24)19-31-16-6-7-21(18-31)17-20-12-14-23(28)15-13-20/h4-5,10-15,21-22,24H,2-3,6-9,16-19H2,1H3,(H2,29,30,32)/t21-,22-,24+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of calcium mobilization in human eosinophils				J Med Chem 48: 2194-211 (2005) Article DOI: 10.1021/jm049530m BindingDB Entry DOI: 10.7270/Q2XP74F1
					More data for this Ligand-Target Pair
C-C chemokine receptor type 3 (Homo sapiens (Human))	BDBM50163651 (1-{(1R,2S)-2-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-...) Show SMILES COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 Show InChI InChI=1S/C27H36FN3O2/c1-33-26-11-5-4-10-25(26)30-27(32)29-24-9-3-2-8-22(24)19-31-16-6-7-21(18-31)17-20-12-14-23(28)15-13-20/h4-5,10-15,21-22,24H,2-3,6-9,16-19H2,1H3,(H2,29,30,32)/t21-,22-,24+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells				J Med Chem 48: 2194-211 (2005) Article DOI: 10.1021/jm049530m BindingDB Entry DOI: 10.7270/Q2XP74F1
					More data for this Ligand-Target Pair